ArticleClinical and experimental immunology1991
Granulocyte-macrophage colony-stimulating factor augments neutrophil killing of Torulopsis glabrata and stimulates neutrophil respiratory burst and degranulation.
Article in Clinical and experimental immunology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 51 citations in OpenAlex.
- Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Neutrophils Require Activation to Express Functional Cell-Surface Complement Receptor Immunoglobulin.Frontiers in immunology · 2022Article
- Distinct Effects of Integrins αXβ2 and αMβ2 on Leukocyte Subpopulations during Inflammation and Antimicrobial Responses.Infection and immunity · 2017Article
- Multiple Phenotypic Changes Define Neutrophil Priming.Frontiers in cellular and infection microbiology · 2017Review
- Granulocyte-macrophage colony-stimulating factor: not just another haematopoietic growth factor.Medical oncology (Northwood, London, England) · 2014Review
- Thriving within the host: Candida spp. interactions with phagocytic cells.Medical microbiology and immunology · 2013Review
- Regulation of innate immune response to Candida albicans infections by αMβ2-Pra1p interaction.Infection and immunity · 2011Article
- Mechanisms of the in vitro fungicidal effects of human neutrophils against Penicillium marneffei induced by granulocyte-macrophage colony-stimulating factor (GM-CSF).Clinical and experimental immunology · 2000Article
- Tumor necrosis factor priming of peripheral blood neutrophils from rheumatoid arthritis patients.Journal of clinical immunology · 1996Article
- Treatment of disseminated Torulopsis glabrata infection with DO870 and amphotericin B.Antimicrobial agents and chemotherapy · 1994Article
- Hepatocyte growth factor stimulates neutrophil degranulation but not respiratory burst.Mediators of inflammation · 1993Article
- The role of GM-CSF in infection.Infection · 1992Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on the interaction between the fungus Torulopsis glabrata and human neutrophils was examined. Pre-incubation of neutrophils with GM-CSF increased the neutrophil fungal killing. The cytokine also increased the oxygen-dependent respiratory burst in response to opsonized fungi, measured by the lucigenin-dependent chemiluminescence assay and superoxide release. Under the same conditions the cytokine augmented release of constituents from both specific and azurophilic granules. Besides these priming effects, GM-CSF was a weak stimulus of the neutrophil respiratory burst and degranulation. The priming and stimulatory effects of GM-CSF were observed at 10-1000 U/ml with an optimal concentration of 100 U/ml.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.