ArticleJournal of bone and mineral metabolism2008
Physical fitness effect on bone mass is mediated by the independent association between lean mass and bone mass through adolescence: a cross-sectional study.
Article in Journal of bone and mineral metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- A Systematic Analysis of Temporal Trends in the Handgrip Strength of 2,216,320 Children and Adolescents Between 1967 and 2017.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- NEUROMUSCULAR FITNESS IN EARLY LIFE AND ITS IMPACT ON BONE HEALTH IN ADULTHOOD: A SYSTEMATIC REVIEW.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020Pooled it
- Conceptual Model of Lean Body Mass in Pediatric Inflammatory Bowel Disease.Journal of pediatric gastroenterology and nutrition · 2019Pooled it
- The health benefits of muscular fitness for children and adolescents: a systematic review and meta-analysis.Sports medicine (Auckland, N.Z.) · 2014Pooled it
- Effect of fitness and physical activity on bone mass in adolescents: the HELENA Study.European journal of applied physiology · 2011Trial
- Lean and fat mass associations with areal bone mineral density in adolescent team sport athletes.Journal of bone and mineral metabolism · 2026Article
- Lower body muscular strength as a predictor of health indicators in youth population: A systematic review and meta-analysis.Sports medicine and health science · 2026Review
- The associations between speed performance and health outcomes in children and adolescents: A systematic review and meta-analysis.Journal of exercise science and fitness · 2026Review
- The association between osteoporosis and quality of life among older adults in Southern Iran: findings from the Bushehr Elderly Health Program.BMC geriatrics · 2024Article
- Muscle Mass as a Biomarker for Health Status and Function in Pediatric Individuals with Neuromuscular Disabilities: A Systematic Review.Children (Basel, Switzerland) · 2024Review
- Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors: The iBoneFIT project.Journal of sport and health science · 2024Article
- Interrelationship between muscle fitness in childhood and bone mineral density in adulthood: mediation analysis of muscle fitness in adulthood.BMC public health · 2023Article
- Speed, agility, and musculoskeletal fitness are independently associated with areal bone mineral density in children.Frontiers in physiology · 2023Article
- Effects of 8-week increment aerobic exercise program on bone metabolism and body composition in young non-athletes.European journal of applied physiology · 2022Article
- Sprint and upper limbs power field tests for the screening of low bone mineral density in children.Frontiers in physiology · 2022Article
- Percentile Curves for Multiple Physical Fitness Components Among Chinese Han Children and Adolescents Aged 7-18 Years From a National Survey Based on the Total and the Normal Weight Population.Frontiers in nutrition · 2021Article
- Rotary-jet spun polycaprolactone/nano-hydroxyapatite scaffolds modified by simulated body fluid influenced the flexural mode of the neoformed bone.Journal of materials science. Materials in medicine · 2020Article
- Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness.Pediatric research · 2020Article
- Is Playing Soccer More Osteogenic for Females Before the Pubertal Spurt?Journal of human kinetics · 2019Article
- The relationships between bone variables and physical fitness across the BMI spectrum in young adult women.Journal of bone and mineral metabolism · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied 278 adolescents (169 females) aged 13.0-18.5 years to elucidate whether an independent effect of physical fitness and lean mass in the differences between male and female bones can be detected. Lean and fat masses and bone mineral content (BMC) were measured with DXA. Physical fitness was evaluated with six different tests included in the EUROFIT test battery (flexibility, isometric, dynamic and endurance strength, speed, and cardiovascular fitness). To test the independent relationship between physical fitness and bone mass, multiple regression analysis was applied, including lean mass, age, and Tanner development as covariates. The males had a 43% lower fat mass and 40% and 16% higher lean mass and total BMC compared with the females (all P < 0.05). After adjustment for differences in body size and lean mass, the females exhibited a 7.4% higher BMC than the males (P < 0.05). The multiple regression analysis showed that lean mass had an independent relationship with bone mass (P < 0.001), explaining 67% of the total variance in whole-body BMC. In males, change in R (2) was 0.658 for hand grip and 0.035-0.151 for the rest of physical fitness-related variables; but 0.019-0.042 in females (all P-0.001); however, the independent relationships between physical fitness and bone disappeared after controlling for lean mass. In conclusion, it is likely the differences between male and female in bone mass could be explained by differences in lean mass and physical fitness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.