GuidelineSchmerz (Berlin, Germany)2008
[Etiology and pathophysiology of fibromyalgia syndrome and chronic widespread pain].
Guideline in Schmerz (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- [Etiology and pathophysiology of fibromyalgia syndrome].Schmerz (Berlin, Germany) · 2012Guideline
- The role of antidepressants in the management of fibromyalgia syndrome: a systematic review and meta-analysis.CNS drugs · 2012Pooled it
- Effects of Monopolar Dielectric Radiofrequency Signals on the Symptoms of Fibromyalgia: A Single-Blind Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Trial
- Impact of Manual Therapy on Plantar Pressures in Patients with Fibromyalgia: A Single-Arm, Non-Randomized Pilot Clinical Trial.Healthcare (Basel, Switzerland) · 2025Article
- A mouse model of chronic primary pain that integrates clinically relevant genetic vulnerability, stress, and minor injury.Science translational medicine · 2024Article
- Pharmacological treatments of fibromyalgia in adults; overview of phase IV clinical trials.Frontiers in pharmacology · 2022Review
- Motivational Non-directive Resonance Breathing as a Treatment for Chronic Widespread Pain.Frontiers in psychology · 2019Article
- Sustained stimulation of βBrain, behavior, and immunity · 2018Article
- Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice.Neuroscience · 2017Article
- Genetic and epigenetic epidemiology of chronic widespread pain.Journal of pain research · 2017Review
- Palmitoylethanolamide in Fibromyalgia: Results from Prospective and Retrospective Observational Studies.Pain and therapy · 2015Article
- Programmed symptoms: disparate effects united by purpose.Current rheumatology reviews · 2015Review
- Multisystem dysregulation in painful temporomandibular disorders.The journal of pain · 2013Article
- Brain-derived neurotrophic factor and exercise in fibromyalgia syndrome patients: a mini review.Rheumatology international · 2012Review
- Article
- The hypothalamus: specific or nonspecific role in the pathophysiology of trigeminal autonomic cephalalgias?Current pain and headache reports · 2011Review
- [Comorbid depression mediates the association of childhood/adolescent maltreatment and fibromyalgia syndrome. A study with patients from different clinical settings].Schmerz (Berlin, Germany) · 2010Article
- [CNS processing of pain in functional somatic syndromes].Schmerz (Berlin, Germany) · 2010Review
- Critical role of nociceptor plasticity in chronic pain.Trends in neurosciences · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo write a systematic review on the etiology and pathophysiology of the fibromyalgia syndrome (FMS) and of chronic widespread pain (CWP).
methodsAn interdisciplinary level-3 guideline (i.e. systematic literature search and assessment, logic analysis, formal consensus procedure) for the diagnosis and therapy of FMS was created in cooperation with 10 medical and psychological societies and 2 patient self-help organizations. A literature search was performed covering all available review articles on the etiology and pathophysiology of FMS and CWP using the Cochrane Collaboration Reviews (1993-12/2006), Medline (1980-2006), PsychInfo (1966-12/2006), and Scopus (1980-12/2006). For the assignment of evidence classes the system of the Oxford Centre for Evidence-Based Medicine was applied. Consensus was achieved by a multi-step nominal group procedure.
resultsFMS aggregates in families (evidence level 2c). Physical and psychological stress at the workplace are risk factors for the development of CWP and FMS. Affective disorders are risk factors for the development and maintenance of FMS. Operant learning mechanisms and sensitization are risk factors for the chronification of FMS (evidence levels 2b). Several factors are associated with the pathophysiology of FMS, but the causal relationship is unclear. This includes alterations of central pain pathways, hyporeactivity of the hypothalamus-pituitary-adrenal axis, increased systemic pro-inflammatory and reduced anti-inflammatory cytokine profiles and disturbances in the dopaminergic and serotonergic systems.
conclusionsFMS is the common final product of various etiological factors and pathophysiological mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.