ArticleEnvironmental health perspectives2008
Prenatal organochlorine exposure and measures of behavior in infancy using the Neonatal Behavioral Assessment Scale (NBAS).
Article in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pesticide exposure and neurodevelopmental outcomes: review of the epidemiologic and animal studies.Journal of toxicology and environmental health. Part B, Critical reviews · 2013Pooled it
- Impact of antenatal exposure to a mixture of endocrine disruptors on attentional and executive functions in children.Journal of the Endocrine Society · 2026Article
- Neuromotor effects of early-life exposure to a mixture of endocrine disruptors in Belgian preschool children.Environmental health : a global access science source · 2025Article
- Multiple prenatal exposures and acute-care clinical encounters for asthma among children born to mothers living near a Superfund site.American journal of epidemiology · 2024Article
- Trajectories of brain and behaviour development in the womb, at birth and through infancy.Nature human behaviour · 2024Review
- Association between pre- and postnatal exposure to endocrine-disrupting chemicals and birth and neurodevelopmental outcomes: an extensive review.Clinical and experimental pediatrics · 2024Article
- Article
- Associations of Prenatal Chemical and Nonchemical Stressors with Early-Adulthood Anxiety and Depressive Symptoms.Environmental health perspectives · 2023Article
- In-utero exposure to DDT and pyrethroids and child behavioral and emotional problems at 2 years of age in the VHEMBE cohort, South Africa.Chemosphere · 2022Article
- Maternal serum persistent organic pollutant exposure and offspring diagnosed ADHD in a national birth cohort.Environmental research · 2022Article
- Early infant behavioural correlates of social skills in adolescents.Paediatric and perinatal epidemiology · 2021Article
- A framework for assessing the impact of chemical exposures on neurodevelopment in ECHO: Opportunities and challenges.Environmental research · 2020Review
- Serum concentrations and detection rates of selected organochlorine pesticides in a sample of Greek school-aged children with neurodevelopmental disorders.Environmental science and pollution research international · 2019Article
- Using Birth Cohort Data to Estimate Prenatal Chemical Exposures for All Births around the New Bedford Harbor Superfund Site in Massachusetts.Environmental health perspectives · 2019Article
- Observational
- Statistical Survey of Persistent Organic Pollutants: Risk Estimations to Humans and Wildlife through Consumption of Fish from U.S. Rivers.Environmental science & technology · 2017Article
- Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on anxiety-related behaviors in larval zebrafish.Neurotoxicology · 2016Article
- The NIEHS Superfund Research Program: 25 Years of Translational Research for Public Health.Environmental health perspectives · 2015Article
- Linking environmental exposure with public health: dichlorodiphenyltrichloroethane extracted from soils and water of recently exposed communities of selected locations in Zambia.Journal of environmental and public health · 2015Article
- Concurrent fetal exposure to multiple environmental chemicals along the U.S.-Mexico border: an exploratory study in Brownsville, Texas.International journal of environmental research and public health · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundPrevious literature suggests an association between organochlorines and behavioral measures in childhood, including inattention.
objectiveThis study was designed to assess whether prenatal organochlorine exposure is associated with measures of attention in early infancy.
methodsWe investigated an association between cord serum polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyl dichloroethene (DDE) levels and measures of attention from the Neonatal Behavioral Assessment Scale (NBAS) in a cohort of 788 infants born 1993-1998 to mothers residing near a PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts.
resultsMedians (ranges) for the sum of four prevalent PCB congeners and DDE levels were 0.19 (0.01-4.41) and 0.30 (0-10.29) ng/g serum, respectively. For the 542 subjects with an NBAS exam at 2 weeks, we observed consistent inverse associations between cord serum PCB and DDE levels and NBAS measures of alertness, quality of alert responsiveness, cost of attention, and other potential attention-associated measures including self-quieting and motor maturity. For example, the decrement in quality of alert responsiveness score was -0.51 (95% confidence interval, -0.99 to -0.03) for the highest quartile of exposure to the sum of four prevalent PCB congeners compared with the lowest quartile. We found little evidence for an association with infant orientation, habituation, and regulation of state, assessed as summary cluster measures.
conclusionsOur findings provide evidence for an association between low-level prenatal PCB and DDE exposures and poor attention in early infancy. Further analyses will focus on whether organochlorine-associated decrements in attention and attention-related skills in infancy persist in later childhood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.