Evidence map›Paper›PMID 18469817›Full record

ArticleNature immunology2008

Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.

Rupesh H Amin, Mark S Schlissel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 276 citations in OpenAlex.

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  15. The Function of E2A in B-Cell Development.Advances in experimental medicine and biology · 2024
    Review
  16. Article
  17. The dynamic functions of IRF4 in B cell malignancies.Clinical and experimental medicine · 2023
    Review
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  19. Article
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117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rupesh H AminDepartment of Molecular & Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA.
Mark S Schlissel
University of California, Berkeley · US

Funding

The Regulation of B Lymphocyte DevelopmentR01HL048702 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI SCHLISSEL, MARK S. · 1994 to 2011
$4.1M
c-Abl and PKC-eta in Cell Development and LeukemiaR01AI057487 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SCHLISSEL, MARK S. · 2004 to 2008
$1.8M
NHLBI NIH HHS R01 HL048702NHLBI NIH HHS R01 HL48702NIAID NIH HHS R01 AI057487NIAID NIH HHS R01 AI57487
6 · The paper itself

Abstract

Regulated expression of the recombinase RAG-1 and RAG-2 proteins is necessary for generating the vast repertoire of antigen receptors essential for adaptive immunity. Here, a retroviral cDNA library screen showed that the stress-regulated protein GADD45a activated transcription of the genes encoding RAG-1 and RAG-2 in transformed pro-B cells by a pathway requiring the transcription factor Foxo1. Foxo1 directly activated transcription of the Rag1-Rag2 locus throughout early B cell development, and a decrease in Foxo1 protein diminished the induction of Rag1 and Rag2 transcription in a model of receptor editing. We also found that transcription of Rag1 and Rag2 was repressed at the pro-B cell and immature B cell stages by the kinase Akt through its 'antagonism' of Foxo1 function. Thus, Foxo1 is a key regulator of Rag1 and Rag2 transcription in primary B cells.

Indexed as

B-LymphocytesCell DifferentiationForkhead Box Protein O1Forkhead Transcription FactorsGene Expression RegulationGenes, RAG-1Receptors, Antigen, B-CellRecombination, GeneticTranscription, GeneticForkhead Box Protein O1Forkhead Transcription FactorsFOXO1 protein, humanReceptors, Antigen, B-Cell

Identifiers

PMID18469817
PMCPMC2612116
OpenAlexW1970116602

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.