ArticleJournal of bacteriology2008
Lipoprotein signal peptides are processed by Lsp and Eep of Streptococcus uberis.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Predatory myxobacteria lay at the cross-roads of metallo-β-lactamase evolution.Communications biology · 2026Article
- Advances in Small Molecule Inhibitors Targeting the Bacterial Lipoprotein Transport System (Lol) in Gram-Negative Bacteria.Chemistry, an Asian journal · 2025Review
- LP30K protein manifested in hemocytes of3 Biotech · 2023Article
- The role of site-2-proteases in bacteria: a review on physiology, virulence, and therapeutic potential.microLife · 2023Review
- Roles of the Site 2 Protease Eep in Staphylococcus aureus.Journal of bacteriology · 2020Article
- Impact of Cell Surface Molecules on Conjugative Transfer of the Integrative and Conjugative Element ICEApplied and environmental microbiology · 2018Article
- An ABC transporter is required for secretion of peptide sex pheromones in Enterococcus faecalis.mBio · 2014Article
- Secretion of bacterial lipoproteins: through the cytoplasmic membrane, the periplasm and beyond.Biochimica et biophysica acta · 2014Review
- Genetic redundancy, proximity, and functionality of lspA, the target of antibiotic TA, in the Myxococcus xanthus producer strain.Journal of bacteriology · 2014Article
- Function of site-2 proteases in bacteria and bacterial pathogens.Biochimica et biophysica acta · 2013Review
- Extracellular identification of a processed type II ComR/ComS pheromone of Streptococcus mutans.Journal of bacteriology · 2012Article
- A phylum level analysis reveals lipoprotein biosynthesis to be a fundamental property of bacteria.Protein & cell · 2012Review
- Use of recombinase-based in vivo expression technology to characterize Enterococcus faecalis gene expression during infection identifies in vivo-expressed antisense RNAs and implicates the protease Eep in pathogenesis.Infection and immunity · 2012Article
- Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development.PLoS pathogens · 2011Article
- New insights into S2P signaling cascades: regulation, variation, and conservation.Protein science : a publication of the Protein Society · 2010Review
- Contribution of lipoproteins and lipoprotein processing to endocarditis virulence in Streptococcus sanguinis.Journal of bacteriology · 2009Article
- Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms.Nature reviews. Microbiology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Lipoprotein signal peptidase (lsp) is responsible for cleaving the signal peptide sequence of lipoproteins in gram-positive bacteria. Investigation of the role of Lsp in Streptococcus uberis, a common cause of bovine mastitis, was undertaken using the lipoprotein MtuA (a protein essential for virulence) as a marker. The S. uberis lsp mutant phenotype displayed novel lipoprotein processing. Not only was full-length (uncleaved) MtuA detected by Western blotting, but during late log phase, a lower-molecular-weight derivative of MtuA was evident. Similar analysis of an S. uberis double mutant containing insertions disrupting both lsp and eep (a homologue of the Enterococcus faecalis "enhanced expression of pheromone" gene) indicated a role for eep in cleavage of lipoproteins in the absence of Lsp. Such a function may indicate a role for eep in maintenance of secretion pathways during disruption of normal lipoprotein processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.