ArticleBiophysical journal2008
Simulated de novo assembly of golgi compartments by selective cargo capture during vesicle budding and targeted vesicle fusion.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Morphological determinants of glycosylation efficiency in Golgi cisternae.PLoS computational biology · 2026Article
- Theoretical approaches for understanding the self-organized formation of the Golgi apparatus.Development, growth & differentiation · 2023Review
- Numerical analysis of the impact of cytoskeletal actin filament density alterations onto the diffusive vesicle-mediated cell transport.PLoS computational biology · 2021Article
- Golgi apparatus self-organizes into the characteristic shape via postmitotic reassembly dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Nonequilibrium description of de novo biogenesis and transport through Golgi-like cisternae.Scientific reports · 2016Article
- Computational analysis of the roles of ER-Golgi network in the cell cycle.BMC systems biology · 2014Article
- New organelles by gene duplication in a biophysical model of eukaryote endomembrane evolution.Biophysical journal · 2013Article
- Three-dimensional stochastic off-lattice model of binding chemistry in crowded environments.PloS one · 2012Article
- Spatial modeling of vesicle transport and the cytoskeleton: the challenge of hitting the right road.PloS one · 2012Article
- Trafficking motifs as the basis for two-compartment signaling systems to form multiple stable states.Biophysical journal · 2011Article
- Analysis and verification of the HMGB1 signaling pathway.BMC bioinformatics · 2010Article
- Conserved molecular mechanisms underlying homeostasis of the Golgi complex.International journal of cell biology · 2010Article
- Discrete, continuous, and stochastic models of protein sorting in the Golgi apparatus.Physical review. E, Statistical, nonlinear, and soft matter physics · 2010Article
- Membrane traffic within the Golgi apparatus.Annual review of cell and developmental biology · 2009Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The Golgi apparatus is comprised of stacked cisternal membranes forming subcompartments specialized for posttranslational processing of newly synthesized secretory cargo. Recent experimental evidence indicates that the Golgi apparatus can undergo de novo biogenesis from the endoplasmic reticulum, but the mechanism by which the membranes self assemble into compartmentalized structures remains unknown. We developed a discrete-event computer simulation model to test whether two fundamental mechanisms-vesicle-coat-mediated selective concentration of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins during vesicle formation, and SNARE-mediated selective fusion of vesicles-suffice to generate and maintain compartments. Simulations verified that this minimal model is adequate for homeostasis of preestablished compartments, even in response to small perturbations, and for de novo formation of stable compartments. The model led to a novel prediction that Golgi size is in part dependent on target SNARE expression level. This prediction was supported by a demonstration that exogenous expression of the Golgi target SNARE syntaxin-5 alters Golgi size in living cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.