ArticleThe Journal of clinical investigation1991
Disparate effects of interferon-gamma and tumor necrosis factor-alpha on early neutrophil respiratory burst and fungicidal responses to Candida albicans hyphae in vitro.
Article in The Journal of clinical investigation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 97 citations in OpenAlex.
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- Non-canonical activation of IRE1α duringbioRxiv : the preprint server for biology · 2024Article
- Renal CD169Life science alliance · 2021Article
- Role of Exercise Intensity on Th1/Th2 Immune Modulations During the COVID-19 Pandemic.Frontiers in immunology · 2021Review
- Lessons Learned from Protective Immune Responses to Optimize Vaccines against Cryptosporidiosis.Pathogens (Basel, Switzerland) · 2017Review
- Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection.Mucosal immunology · 2015Article
- Immune defence mechanisms and immunoenhancement strategies in oropharyngeal candidiasis.Expert reviews in molecular medicine · 2008Review
- Protein synthesis inhibition as a potential strategy for metabolic down-regulation.Resuscitation · 2007Article
- Review
- Catalases of Aspergillus fumigatus.Infection and immunity · 2003Article
- The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans.Journal of bacteriology · 1999Article
- Tumor necrosis factor alpha enhances antifungal activities of polymorphonuclear and mononuclear phagocytes against Aspergillus fumigatus.Infection and immunity · 1998Article
- Cloning and sequencing of a Candida albicans catalase gene and effects of disruption of this gene.Infection and immunity · 1998Article
- Macrophages in resistance to candidiasis.Microbiology and molecular biology reviews : MMBR · 1997Review
- Gamma interferon is not essential in host defense against disseminated candidiasis in mice.Infection and immunity · 1997Article
- Gamma interferon protects endothelial cells from damage by Candida albicans by inhibiting endothelial cell phagocytosis.Infection and immunity · 1996Article
- Tumor necrosis factor primes neutrophils to kill Staphylococcus aureus by an oxygen-dependent mechanism and Plasmodium falciparum by an oxygen-independent mechanism.Infection and immunity · 1996Article
- Tumor necrosis factor priming of peripheral blood neutrophils from rheumatoid arthritis patients.Journal of clinical immunology · 1996Article
- gamma Interferon gene expression and release in human lymphocytes directly activated by Cryptococcus neoformans and Candida albicans.Infection and immunity · 1996Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We examined effects of priming with recombinant human interferon-gamma (IFN) or tumor necrosis factor-alpha (TNF) on neutrophil responses to Candida albicans hyphae. Both cytokines increased early superoxide generation after hyphal stimulation. The more pronounced effects of TNF were accompanied by an augmented surface membrane depolarization rate and were insensitive to both pertussis toxin and calcium ion chelation, but were negated by concomitant incubation with puromycin or cycloheximide during priming. IFN augmented hyphal killing despite its only minor enhancement of early respiratory burst responses, but TNF reduced neutrophil fungicidal activity to nearly 40% below those by unprimed control cells even though it enhanced early superoxide responses more dramatically. Though TNF-primed neutrophils killed hyphae at normal initial rates, IFN-primed or even unprimed cells manifested more fungicidal sustained activity. These disparate consequences of cytokine priming on hyphal destruction were paralleled by differences in late generation of potentially candidacidal oxidants, hydrogen peroxide, and hypochlorous acid. IFN added during priming failed to correct TNF-associated functional defects in neutrophil anti-Candida responses. Thus, augmentation of early respiratory burst responses to oxidant-sensitive organisms need not necessarily reflect concomitant salutary effects on microbicidal activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.