ArticleArchives of biochemistry and biophysics2008
Proteasome inhibitors induce apoptosis of prostate cancer cells by inducing nuclear translocation of IkappaBalpha.
Article in Archives of biochemistry and biophysics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Decoding NF-κB: nucleocytoplasmic shuttling dynamics, synthetic modulation and post-therapeutic behavior in cancer.Molecular biology reports · 2025Review
- Apelin inhibited epithelial-mesenchymal transition of podocytes in diabetic mice through downregulating immunoproteasome subunits β5i.Cell death & disease · 2018Article
- Article
- Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation.Brain, behavior, and immunity · 2015Article
- EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism.Scientific reports · 2015Article
- IKK inhibition increases bortezomib effectiveness in ovarian cancer.Oncotarget · 2015Article
- Bcl3 regulates pro-survival and pro-inflammatory gene expression in cutaneous T-cell lymphoma.Biochimica et biophysica acta · 2014Article
- Proteasome inhibition increases recruitment of IκB kinase β (IKKβ), S536P-p65, and transcription factor EGR1 to interleukin-8 (IL-8) promoter, resulting in increased IL-8 production in ovarian cancer cells.The Journal of biological chemistry · 2014Article
- Preclinical evaluation of 4-[3,5-bis(2-chlorobenzylidene)-4-oxo-piperidine-1-yl]-4-oxo-2-butenoic acid, in a mouse model of lung cancer xenograft.British journal of pharmacology · 2013Article
- NFκB function and regulation in cutaneous T-cell lymphoma.American journal of cancer research · 2013Review
- Proteasome inhibition by bortezomib increases IL-8 expression in androgen-independent prostate cancer cells: the role of IKKα.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF Kappa B pathway and proteasome activity.British journal of haematology · 2013Article
- Caspase control: protagonists of cancer cell apoptosis.Experimental oncology · 2012Review
- Regulation and function of nuclear IκBα in inflammation and cancer.American journal of clinical and experimental immunology · 2012Article
- Bortezomib induces nuclear translocation of IκBα resulting in gene-specific suppression of NF-κB--dependent transcription and induction of apoptosis in CTCL.Molecular cancer research : MCR · 2011Article
- Gene-specific repression of proinflammatory cytokines in stimulated human macrophages by nuclear IκBα.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Cancer biomarker discovery: the entropic hallmark.PloS one · 2010Article
- Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival.Journal of neuroscience research · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Proteasome inhibitors are known to suppress the proteasome-mediated degradation of IkappaBalpha in stimulated cells. This results in the cytoplasmic retention of NFkappaB and its reduced nuclear transcriptional activity. In this study, we show that in the metastatic prostate cancer cells, the proteasome inhibitors exhibit a novel, previously unrecognized effect: they increase the cellular levels of IkappaBalpha, which then translocates to the nucleus, associates with the nuclear p65 NFkappaB, thus inhibiting the constitutive NFkappaB DNA binding activity and inducing apoptosis. The proteasome inhibition-induced nuclear translocation of IkappaBalpha is dependent on de novo protein synthesis, occurs also in other cell types, and does not require IkappaBalpha phosphorylation on Ser-32. Since NFkappaB activity is constitutively increased in many human cancers as well as in inflammatory disorders, the proteasome inhibition-induced nuclear translocation of IkappaBalpha could thus provide a new therapeutic strategy aimed at the specific inhibition of NFkappaB activity by the nuclear IkappaBalpha.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.