Evidence map›Paper›PMID 18468440›Full record

ReviewTrends in cell biology2008

Reverse leukocyte migration can be attractive or repulsive.

Anna Huttenlocher, Mark C Poznansky

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anna HuttenlocherDepartment of Medical Microbiology and Immunology and Pediatrics, University of Wisconsin-Madison, 4205 Microbial Science Building, 1550 Linden Drive, Madison, WI 53706, USA. huttenlocher@wisc.edu
Mark C Poznansky

Funding

HIV-1 gp120 induced CTL chemorepulsion:dysregulation of migration & localizationR01AI049757 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI POZNANSKY, MARK COLEMAN · 2001 to 2010
$4.0M
Neutrophil Chemotaxis in AutoinflammationR01GM074827 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HUTTENLOCHER, ANNA · 2005 to 2015
$3.3M
NIAID NIH HHS R01 AI049757NIAID NIH HHS R01 AI49757NIGMS NIH HHS R01 GM074827
6 · The paper itself

Abstract

The directional migration of cells within multicellular organisms is governed by gradients of both chemical attractants and repellents in diverse processes, including leukocyte trafficking and neuronal pathfinding in vivo. These complex extracellular environments direct the orchestrated bidirectional trafficking of leukocytes between the vasculature and tissues. Substantial progress has been made in dissecting the molecular mechanisms involved in orchestrating the directed movement of leukocytes into host tissues; however, less is known about the reverse migration of leukocytes from the tissues to the vasculature. In this article, we discuss the functional interplay between chemoattraction and chemorepulsion in the bidirectional movement of cells in complex in vivo environments, and we describe how these mechanisms influence both normal physiology and human disease.

Indexed as

AnimalsAxonsCell AdhesionCell CommunicationCell MovementCell ProliferationChemotactic FactorsChemotaxisChemotaxis, LeukocyteHumansImmune SystemLeukocytesModels, BiologicalZebrafishChemotactic Factors

Identifiers

PMID18468440
PMCPMC2435406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.