ArticleAnnals of the rheumatic diseases2009
Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study.
Article in Annals of the rheumatic diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 6 of them syntheses that pooled it.
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Who cites it
159 citing papers in PubMed, 6 syntheses or guidelines pooled it, 372 citations in OpenAlex.
- Causal analysis of body composition measurements in osteoarthritis knee: a two-sample mendelian randomization study.BMC musculoskeletal disorders · 2024Pooled it
- Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies.BMJ open · 2015Pooled it
- Pooled it
- A systematic review of sensorimotor function during adolescence: a developmental stage of increased motor awkwardness?British journal of sports medicine · 2012Pooled it
- Obesity and knee osteoarthritis.Inflammopharmacology · 2012Pooled it
- Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.Annals of the rheumatic diseases · 2011Pooled it
- A novel behavioural INTErvention to REduce Sitting Time in older adults undergoing orthopaedic surgery (INTEREST): results of a randomised-controlled feasibility study.Aging clinical and experimental research · 2020Trial
- Trial
- Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients: a twelve-month randomized controlled trial.Arthritis care & research · 2015Trial
- Changes in bone marrow lesions in response to weight-loss in obese knee osteoarthritis patients: a prospective cohort study.BMC musculoskeletal disorders · 2013Trial
- A comparison of Kneipp hydrotherapy with conventional physiotherapy in the treatment of osteoarthritis of the hip or knee: protocol of a prospective randomised controlled clinical trial.BMC musculoskeletal disorders · 2009Trial
- Does fat mass contribute to knee osteoarthritis risk beyond weight itself? Data from the Multicenter Osteoarthritis Study.Osteoarthritis and cartilage · 2026Article
- Predictive Neuromechanical Simulation Explains Gait Biomechanics in Obesity.bioRxiv : the preprint server for biology · 2026Article
- Metabolic syndrome, accumulation of its components and risk of knee and hip replacement for osteoarthritis in community-dwelling older adults.Osteoarthritis and cartilage open · 2026Article
- The role of metabolic syndrome in osteoarthritis development: Is obesity the key driver?Osteoarthritis and cartilage open · 2026Article
- Mechanical interplay between adipose tissues and disease progression.Bioengineering & translational medicine · 2026Review
- Exercise Guidelines for Enhancing Mobility and Stability in Individuals with Severe Obesity.Journal of obesity & metabolic syndrome · 2026Review
- The Relationship between Joint Loading and Physical Activity Level in Middle-Aged Adults with Obesity, and the Role of Body Composition.Medicine and science in sports and exercise · 2026Article
- Associations of metabolic status with all-cause mortality among individuals with osteoarthritis: A prospective cohort study.Journal of orthopaedic translation · 2025Article
- Differential Pattern of Obesity in Total Hip and Knee Arthroplasty Candidates.Physiotherapy Canada. Physiotherapie Canada · 2025Article
99 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine in a prospective population-based cohort study relationships between different measures of body mass and the incidence of severe knee and hip osteoarthritis defined as arthroplasty of knee or hip due to osteoarthritis. MATERIALS AND
methodsBody mass index (BMI), waist circumference, waist-hip ratio (WHR), weight and percentage of body fat (BF%) were measured at baseline in 11,026 men and 16,934 women from the general population. The incidence of osteoarthritis over 11 years was monitored by linkage with the Swedish hospital discharge register.
results471 individuals had knee osteoarthritis and 551 had hip osteoarthritis. After adjustment for age, sex, smoking and physical activity, the relative risks (RR) of knee osteoarthritis (fourth vs first quartile) were 8.1 (95% CI 5.3 to 12.4) for BMI, 6.7 (4.5 to 9.9) for waist circumference, 6.5 (4.6 to 9.43) for weight, 3.6 (2.6 to 5.0) for BF% and 2.2 (1.7 to 3.0) for WHR. Corresponding RR for hip osteoarthritis were 2.6 (2.0 to 3.4) for BMI, 3.0 (2.3 to 4.0) for weight, 2.5 (1.9 to 3.3) for waist, 1.3 (0.99 to 1.6) for WHR and 1.5 (1.2 to 2.0) for BF%.
conclusionAll measures of overweight were associated with the incidence of knee osteoarthritis, with the strongest relative risk gradient observed for BMI. The incidence of hip osteoarthritis showed smaller but significant differences between normal weight and obesity. Our results support a major link between overweight and biomechanics in increasing the risk of knee and hip osteoarthritis in men and women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.