ArticlePlant physiology2008
Invasion of the Arabidopsis genome by the tobacco retrotransposon Tnt1 is controlled by reversible transcriptional gene silencing.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Transcriptome-wide identification and systematic analysis of the Retrotransposon genes and their roles in ginsenoside biosynthesis in Panax ginseng.BMC plant biology · 2025Article
- Review
- Unravelling the Role of Epigenetic Modifications in Development and Reproduction of Angiosperms: A Critical Appraisal.Frontiers in genetics · 2022Review
- Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation.Molecular cell · 2021Article
- Epigenetics and epigenomics: underlying mechanisms, relevance, and implications in crop improvement.Functional & integrative genomics · 2020Review
- RNA-directed DNA Methylation.PLoS genetics · 2020Article
- Diversity, distribution and dynamics of full-length Copia and Gypsy LTR retroelements in Solanum lycopersicum.Genetica · 2017Article
- Exogenous Transposable Elements Circumvent Identity-Based Silencing, Permitting the Dissection of Expression-Dependent Silencing.The Plant cell · 2017Article
- Genomic localization of AtRE1 and AtRE2, copia-type retrotransposons, in natural variants of Arabidopsis thaliana.Molecular genetics and genomics : MGG · 2014Article
- Epigenetic memory in plants.The EMBO journal · 2014Review
- RNA-directed DNA methylation: an epigenetic pathway of increasing complexity.Nature reviews. Genetics · 2014Review
- Article
- Insertional mutagenesis using Tnt1 retrotransposon in potato.Plant physiology · 2013Article
- Reconstructing de novo silencing of an active plant retrotransposon.Nature genetics · 2013Article
- Co-evolution of plant LTR-retrotransposons and their host genomes.Protein & cell · 2013Review
- Article
- Article
- The stem cell state in plant development and in response to stress.Frontiers in plant science · 2011Article
- Transcriptional activity of transposable elements in maize.BMC genomics · 2010Article
- A synthetic biology approach allows inducible retrotransposition in whole plants.Systems and synthetic biology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long terminal repeat (LTR) retrotransposons are generally silent in plant genomes. However, they often constitute a large proportion of repeated sequences in plants. This suggests that their silencing is set up after a certain copy number is reached and/or that it can be released in some circumstances. We introduced the tobacco (Nicotiana tabacum) LTR retrotransposon Tnt1 into Arabidopsis (Arabidopsis thaliana), thus mimicking the horizontal transfer of a retrotransposon into a new host species and allowing us to study the regulatory mechanisms controlling its amplification. Tnt1 is transcriptionally silenced in Arabidopsis in a copy number-dependent manner. This silencing is associated with 24-nucleotide short-interfering RNAs targeting the promoter localized in the LTR region and with the non-CG site methylation of these sequences. Consequently, the silencing of Tnt1 is not released in methyltransferase1 mutants, in contrast to decrease in DNA methylation1 or polymerase IVa mutants. Stable reversion of Tnt1 silencing is obtained when the number of Tnt1 elements is reduced to two by genetic segregation. Our results support a model in which Tnt1 silencing in Arabidopsis occurs via an RNA-directed DNA methylation process. We further show that silencing can be partially overcome by some stresses.
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