ArticlePlant physiology2008
Functional characterization of HFR1, a high-mannose N-glycan-specific wheat lectin induced by Hessian fly larvae.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 103 citations in OpenAlex.
- Direct avirulence effector-receptor interaction confers wheat immunity against insects.Science advances · 2026Article
- Hessian fly tolerance increases yield in elite durum wheat cultivars Svevo and Soft Svevo.Communications biology · 2026Article
- Genetic and phenotypic responses of temperature-independent Hessian fly-resistant durum wheat to larval attack during heat stress.BMC plant biology · 2025Article
- Article
- Comparative analysis of theFrontiers in plant science · 2024Article
- Genome-Wide and Transcriptome Analysis of Jacalin-Related Lectin Genes in Barley and the Functional Characterization ofInternational journal of molecular sciences · 2023Article
- Transcriptional Profiling Reveals the Wheat Defences against Fusarium Head Blight Disease Regulated by a NAC Transcription Factor.Plants (Basel, Switzerland) · 2023Article
- The Crystal Structure of the Defense Conferring Rice ProteinBiomolecules · 2022Article
- Impact of Heat Stress on Expression of Wheat Genes Responsive to Hessian Fly Infestation.Plants (Basel, Switzerland) · 2022Article
- Comparative Hessian Fly Larval Transcriptomics Provides Novel Insight into Host and Nonhost Resistance.International journal of molecular sciences · 2021Article
- Insect derived extra oral GH32 plays a role in susceptibility of wheat to Hessian fly.Scientific reports · 2021Article
- Identification of monocot chimeric jacalin family reveals functional diversity in wheat.Planta · 2021Article
- Genome-Wide Identification ofFrontiers in plant science · 2021Article
- Article
- Phenotypic and molecular characterization of Hessian fly resistance in diploid wheat, Aegilops tauschii.BMC plant biology · 2019Article
- Combining next-generation sequencing and single-molecule sequencing to explore brown plant hopper responses to contrasting genotypes of japonica rice.BMC genomics · 2019Article
- Multiple molecular defense strategies in Brachypodium distachyon surmount Hessian fly (Mayetiola destructor) larvae-induced susceptibility for plant survival.Scientific reports · 2019Article
- Biomass Accumulation and Cell Wall Structure of Rice Plants Overexpressing a Dirigent-Jacalin of Sugarcane (Frontiers in plant science · 2019Article
- Development of SNP assays for hessian fly response genes, Hfr-1 and Hfr-2, for marker-assisted selection in wheat breeding.BMC genetics · 2018Article
- Mitogenic activity of Artocarpus lingnanensis lectin and its apoptosis induction in Jurkat T cells.Journal of natural medicines · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
We previously cloned and characterized a novel jacalin-like lectin gene from wheat (Triticum aestivum) plants that responds to infestation by Hessian fly (Mayetiola destructor) larvae, a major dipteran pest of this crop. The infested resistant plants accumulated higher levels of Hfr-1 (for Hessian fly-responsive gene 1) transcripts compared with uninfested or susceptible plants. Here, we characterize the soluble and active recombinant His(6)-HFR1 protein isolated from Escherichia coli. Functional characterization of the protein using hemagglutination assays revealed lectin activity. Glycan microarray-binding assays indicated strong affinity of His(6)-HFR1 to Manalpha1-6(Manalpha1-3)Man trisaccharide structures. Resistant wheat plants accumulated high levels of HFR1 at the larval feeding sites, as revealed by immunodetection, but the avirulent larvae were deterred from feeding and consumed only small amounts of the lectin. Behavioral studies revealed that avirulent Hessian fly larvae on resistant plants exhibited prolonged searching and writhing behaviors as they unsuccessfully attempted to establish feeding sites. During His(6)-HFR1 feeding bioassays, Drosophila melanogaster larvae experienced significant delays in growth and pupation, while percentage mortality increased with progressively higher concentrations of His(6)-HFR1 in the diet. Thus, HFR1 is an antinutrient to dipteran larvae and may play a significant role in deterring Hessian fly larvae from feeding on resistant wheat plants.
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