ArticleThe Journal of biological chemistry2008
Decidual cells produce a heparin-binding prolactin family cytokine with putative intrauterine regulatory actions.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Type V Collagen Controls Decidual Extracellular Matrix Organization and Angiogenesis During Embryo Implantation.bioRxiv : the preprint server for biology · 2026Article
- Establishment of Murine Pregnancy Requires the Promyelocytic Leukemia Zinc Finger Transcription Factor.International journal of molecular sciences · 2024Article
- Article
- Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy.PLoS biology · 2019Article
- Murine transcription factor Math6 is a regulator of placenta development.Scientific reports · 2018Article
- HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment.The Journal of clinical investigation · 2018Article
- Hypoxia and Placental Development.Birth defects research · 2017Review
- Origin of a rapidly evolving homeostatic control system programming testis function.The Journal of endocrinology · 2017Article
- Identification of target genes for a prolactin family paralog in mouse decidua.Reproduction (Cambridge, England) · 2015Article
- Placental ischemia induces changes in gene expression in chorionic tissue.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions.The Journal of clinical investigation · 2013Article
- Uterine deletion of Trp53 compromises antioxidant responses in the mouse decidua.Endocrinology · 2012Article
- Neonatally induced mild diabetes in rats and its effect on maternal, placental, and fetal parameters.Experimental diabetes research · 2012Article
- Article
- Subfertility linked to combined luteal insufficiency and uterine progesterone resistance.Endocrinology · 2010Article
- Prolactin family of the guinea pig, Cavia porcellus.Endocrinology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Pregnancy in mice and rats is associated with the production of a large family of hormones/cytokines related to prolactin (PRL). The hormones/cytokines are hypothesized to coordinate maternal and fetal adaptations to pregnancy. In this study, PRL-like protein-J (PLP-J, also known as PRL family 3, subfamily c, member 1 (Prl3c1)) is shown to be a product of the uterine decidua and a regulator of postimplantation intrauterine events. PLP-J-specific antibodies and a series of recombinant PLP-J proteins were generated and used to investigate PLP-J expression and as ligands for investigating biological targets. Decidual PLP-J migrates as a 29-kDa protein and localizes to a band of decidual cells surrounding the trophoblast cell layer on gestation day 8.5. PLP-J ligands specifically bound in situ to the surrounding uterine stromal cells and vasculature within the decidua of gestation day 8.5 implantation sites. We then investigated the in vitro actions of PLP-J on uterine stromal cells and endothelial cells. PLP-J specifically interacted with both cell populations. PLP-J promoted uterine stromal cell proliferation and inhibited endothelial cell proliferation. We determined that PLP-J does not interact with PRL receptors. Instead, PLP-J interacts with heparin-containing molecules, including syndecan-1, which is expressed in gestation day 8.5 pregnant uteri, as well as in uterine stromal cells and endothelial cells. The restricted expression of PLP-J and its specific interactions with uterine stromal cells and endothelial cells suggests that it acts locally and regulates decidual cell development and the endometrial vasculature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.