Evidence map›Paper›PMID 18467168›Full record

ReviewClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2008

Pathophysiology of parkinsonism.

Adriana Galvan, Thomas Wichmann

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 197 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 5 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

197 citing papers in PubMed, 5 syntheses or guidelines pooled it, 537 citations in OpenAlex.

  1. The prevalence of sarcopenia in Parkinson's disease and related disorders- a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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  20. Parkinsonism Disrupts Neuronal Modulation in the Presupplementary Motor Area during Movement Preparation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adriana GalvanDepartment of Neurology, School of Medicine and Division of Sensorimotor Systems, Yerkes National Primate Center, Emory University, Atlanta, GA 30329, United States.
Thomas Wichmann
Emory University · US

Funding

YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
Function of dopamine in the primate substantia nigraR01NS049474 · NINDS · EMORY UNIVERSITY · PI WICHMANN, THOMAS · 2005 to 2009
$1.7M
Local field potentials in the basal gangliaR01NS054976 · NINDS · EMORY UNIVERSITY · PI WICHMANN, THOMAS · 2006 to 2010
$1.7M
Basal ganglia discharge patterns in parkinsonismR01NS042250 · NINDS · EMORY UNIVERSITY · PI WICHMANN, THOMAS N. · 2001 to 2005
$1.5M
NCRR NIH HHS P51 RR000165NCRR NIH HHS RR-000165NINDS NIH HHS NS042250NINDS NIH HHS NS049474NINDS NIH HHS NS054976NINDS NIH HHS R01 NS042250NINDS NIH HHS R01 NS049474NINDS NIH HHS R01 NS054976
6 · The paper itself

Abstract

The motor signs of Parkinson's disease are thought to result in large part from a reduction of the level of dopamine in the basal ganglia. Over the last few years, many of the functional and anatomical consequences of dopamine loss in these structures have been identified, both in the basal ganglia and in related areas in thalamus and cortex. This knowledge has contributed significantly to our understanding of the link between the degeneration of dopamine neurons in the midbrain and the development of parkinsonism. This review discusses the evidence that implicates electrophysiologic changes (including altered discharge rates, increased incidence of burst firing, interneuronal synchrony, oscillatory activity, and altered sensorimotor processing) in basal ganglia, thalamus, and cortex, in parkinsonism. From these studies, parkinsonism emerges as a complex network disorder, in which abnormal activity in groups of neurons in the basal ganglia strongly affects the excitability, oscillatory activity, synchrony and sensory responses of areas of the cerebral cortex that are involved in the planning and execution of movement, as well as in executive, limbic or sensory functions. Detailed knowledge of these changes will help us to develop more effective and specific symptomatic treatments for patients with Parkinson's disease.

Indexed as

AnimalsBasal GangliaBrain StemCerebral CortexElectromyographyElectrophysiologyHumansNerve NetParkinson DiseaseThalamus

Identifiers

PMID18467168
PMCPMC2467461
OpenAlexW1968791710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.