Evidence map›Paper›PMID 18466739›Full record

ReviewNeuron2008

Silencing the cochlear amplifier by immobilizing prestin.

Ulrich Müller, Peter Gillespie

Open access · bronzeAbstract readCommentReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuron, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Reprogramming withPNAS nexus · 2024
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ulrich MüllerDepartment of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. umueller@scripps.edu
Peter Gillespie
Oregon Health & Science University · USScripps Research Institute · US

Funding

Mechanosensor Development, Function, and DysfunctionR01DC005965 · NIDCD · SCRIPPS RESEARCH INSTITUTE, THE · PI MUELLER, ULRICH · 2003 to 2023
$10.2M
Mouse models to study inherited forms of deafnessR01DC007704 · NIDCD · SCRIPPS RESEARCH INSTITUTE, THE · PI MUELLER, ULRICH · 2005 to 2014
$5.0M
NIDCD NIH HHS R01 DC005965NIDCD NIH HHS R01 DC007704
6 · The paper itself

Abstract

Achieving the exquisite sensitivity and frequency selectivity of the mammalian ear requires active amplification of input sound. In this issue of Neuron, Dallos and colleagues demonstrate that the molecular motor prestin, which drives shape changes in the soma of mechanosensory hair cells, underlies mechanical feedback mechanisms for sound amplification in mammals.

Indexed as

AnimalsHair Cells, Auditory, OuterHearingHumansMolecular Motor ProteinsMolecular Motor ProteinsPres protein, mouse

Identifiers

PMID18466739
PMCPMC2888509
OpenAlexW1987090036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.