ArticleHelicobacter2008
Helicobacter pylori-pulsed dendritic cells induce H. pylori-specific immunity in mice.
Article in Helicobacter, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Construction and evaluation of aFrontiers in immunology · 2025Article
- Notch Signaling Regulates the Function and Phenotype of Dendritic Cells inMicroorganisms · 2023Article
- Review
- CCR2 mediates Helicobacter pylori-induced immune tolerance and contributes to mucosal homeostasis.Helicobacter · 2017Article
- Lactic acid bacteria strains exert immunostimulatory effect on H. pylori-induced dendritic cells.Journal of immunology research · 2015Article
- Article
- Impaired dendritic cell maturation and IL-10 production following H. pylori stimulation in gastric cancer patients.Applied microbiology and biotechnology · 2012Article
- IRAK-M modulates expression of IL-10 and cell surface markers CD80 and MHC II after bacterial re-stimulation of tolerized dendritic cells.Immunology letters · 2012Article
- Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection.Frontiers in immunology · 2012Article
- Human primary gastric dendritic cells induce a Th1 response to H. pylori.Mucosal immunology · 2010Article
- Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice.Gastroenterology · 2010Article
- Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe growing concern over the emergence of antibiotic-resistant Helicobacter pylori infection is propelling the development of an efficacious vaccine to control this highly adaptive organism.
aimWe studied the use of a dendritic cell (DC)-based vaccine against H. pylori infection in mice.
methodsThe cellular immune responses to murine bone marrow-derived DCs pulsed with phosphate-buffered saline (PBS-DC) or live H. pylori SS1 (HP-DC) were assessed in vitro and in vivo. The protective immunity against H. pylori SS1 oral challenge was compared between HP-DC or PBS-DC immunized mice. The effect of regulatory T-cell (Treg) depletion by anti-CD25 antibody on HP-DC vaccine efficacy was also evaluated.
resultsHP-DC induced a Th1-dominant response in vitro. In vivo, HP-DC immunized mice were characterized by a mixed Th1/Th2 peripheral immune response. However, in the stomach, HP-DC immunized mice expressed a higher level of IFN-gamma compared to PBS-DC immunized mice; no difference was found for interleukin-5 expressions in the stomach. A lower bacterial colonization post-H. pylori challenge was observed in HP-DC immunized mice compared to PBS-DC immunized mice with no significant difference in gastritis severity. H. pylori-specific Th1 response and protective immunity were further enhanced in vivo by depletion of Treg with anti-CD25 antibody.
conclusionDC-based anti-H. pylori vaccine induced H. pylori-specific helper T-cell responses capable of limiting bacterial colonization. Our data support the critical role of effector cellular immune response in the development of H. pylori vaccine.
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Registered trials
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