ArticleParasite immunology
Distinct pattern of class and subclass antibodies in immune complexes of children with cerebral malaria and severe malarial anaemia.
Article in Parasite immunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 29 citations in OpenAlex.
- Lack of iron, zinc, and vitamins as a contributor to the etiology of atopic diseases.Frontiers in nutrition · 2022Review
- Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia.JCI insight · 2018Article
- Peculiarities of the formation and subsequent removal of the circulating immune complexes from the bloodstream during the process of digestion.F1000Research · 2018Article
- No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes.Scientific reports · 2017Article
- Article
- Dual role of erythrocyte complement receptor type 1 in immune complex-mediated macrophage stimulation: implications for the pathogenesis of Plasmodium falciparum malaria.Clinical and experimental immunology · 2011Article
- Duality and complexity of allergic type inflammatory mechanisms in determining the outcome of malaria disease.Frontiers in immunology · 2011Article
- The levels of CD16/Fc gamma receptor IIIA on CD14+ CD16+ monocytes are higher in children with severe Plasmodium falciparum anemia than in children with cerebral or uncomplicated malaria.Infection and immunity · 2010Article
- Antibody-dependent transplacental transfer of malaria blood-stage antigen using a human ex vivo placental perfusion model.PloS one · 2009Article
- Blood groups and malaria: fresh insights into pathogenesis and identification of targets for intervention.Current opinion in hematology · 2009Review
- When is a malaria immune complex not an immune complex?Parasite immunology · 2009Article
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4 authors at 3 institutions in 2 countries.
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Abstract
Plasmodium falciparum infection can lead to deadly complications such as severe malaria-associated anaemia (SMA) and cerebral malaria (CM). Children with severe malaria have elevated levels of circulating immune complexes (ICs). To further investigate the quantitative differences in antibody class/subclass components of ICs in SMA and CM, we enrolled 75 children with SMA and 32 children with CM from hospitals in western Kenya and matched them to 74 and 52 control children, respectively, with uncomplicated symptomatic malaria. Total IgG IC levels were always elevated in children with malaria upon enrollment, but children with CM had the highest levels of any group. Conditional logistic regression showed a borderline association between IgG4-containing IC levels and increased risk of SMA (OR = 3.11, 95% CI 1.01-9.56, P = 0.05). Total IgG ICs (OR = 2.84, 95% CI 1.08-7.46, P = 0.03) and IgE-containing ICs (OR = 6.82, OR 1.88-24.73, P < or = 0.01) were associated with increased risk of CM. These results point to differences in the contribution of the different antibody class and subclass components of ICs to the pathogenesis of SMA and CM and give insight into potential mechanisms of disease.
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