ArticleApoptosis : an international journal on programmed cell death2008
p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription.
Article in Apoptosis : an international journal on programmed cell death, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- FOXO transcription factors in Alzheimer's Disease: balancing neuroprotection and neuronal degeneration.Molecular biology reports · 2026Review
- Stress Relief Techniques: p38 MAPK Determines the Balance of Cell Cycle and Apoptosis Pathways.Biomolecules · 2021Review
- The Effect of Caffeic Acid on Spermatogonial Stem Cell-type A Cryopreservation.Reports of biochemistry & molecular biology · 2018Article
- Blockade of ITGA2 Induces Apoptosis and Inhibits Cell Migration in Gastric Cancer.Biological procedures online · 2018Article
- Identification of Neuregulin-2 as a novel stress granule component.BMB reports · 2016Article
- Cdk5-Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models.Journal of cell science · 2016Article
- Redox regulation of FoxO transcription factors.Redox biology · 2015Review
- SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.Free radical biology & medicine · 2015Review
- Regulation of Bim in Health and Disease.Oncotarget · 2015Review
- FoxO3a nuclear localization and its association with β-catenin and Smads in IFN-α-treated hepatocellular carcinoma cell lines.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014Article
- Computer-aided targeting of the PI3K/Akt/mTOR pathway: toxicity reduction and therapeutic opportunities.International journal of molecular sciences · 2014Review
- Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies.ISRN hematology · 2013Article
- Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells.Cell death & disease · 2012Article
- Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin.The Journal of biological chemistry · 2012Article
- ID4 regulates mammary gland development by suppressing p38MAPK activity.Development (Cambridge, England) · 2011Article
- OSU-DY7, a novel D-tyrosinol derivative, mediates cytotoxicity in chronic lymphocytic leukaemia and Burkitt lymphoma through p38 mitogen-activated protein kinase pathway.British journal of haematology · 2011Article
- p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis.Science signaling · 2011Article
- Differential roles of Epac in regulating cell death in neuronal and myocardial cells.The Journal of biological chemistry · 2010Article
- Activation of the AMP-activated protein kinase-p38 MAP kinase pathway mediates apoptosis induced by conjugated linoleic acid in p53-mutant mouse mammary tumor cells.Cellular signalling · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sodium arsenite induces apoptosis in PC12 cells by activating the stress-activated p38 MAP kinase and the pro-apoptotic Bcl-2 family protein Bim(EL). However, the relationship between p38 and Bim(EL) in this apoptosis has not been fully defined. Here, we report that sodium arsenite stimulates the protein expression and promoter activity of Bim(EL) in a p38-dependent manner. Sodium arsenite also caused nuclear translocation of FOXO3a, indicative of FOXO3a activation. Addition of a p38 inhibitor prevented FOXO3a nuclear translocation. RNAi knock down of FOXO3a inhibited Bim promoter activity, Bim(EL) protein expression, and arsenite-induced apoptosis. Our data identify p38 activation of FOXO3a and subsequent induction of Bim(EL) expression as a novel apoptotic mechanism. Together with our previous finding that Bim(EL) is phosphorylated and activated by p38, these results demonstrate that p38 induces apoptosis by regulating Bim(EL) at both the transcriptional and post-translational levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.