ArticleJournal of neurology2008
Gene expression in human peripheral blood mononuclear cells upon acute ischemic stroke.
Article in Journal of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Review
- Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis.Neuroradiology · 2022Article
- Consensus clustering of gene expression profiles in peripheral blood of acute ischemic stroke patients.Frontiers in neurology · 2022Article
- Critical role of FPR1 in splenocyte migration into brain to worsen inflammation and ischemic brain injury in mice.Theranostics · 2022Article
- Acute Stroke Biomarkers: Are We There Yet?Frontiers in neurology · 2021Review
- Exploring the Impact of Cerebrovascular Disease and Major Depression on Non-diseased Human Tissue Transcriptomes.Frontiers in genetics · 2021Article
- Characterization of Dysregulated miRNA in Peripheral Blood Mononuclear Cells from Ischemic Stroke Patients.Molecular neurobiology · 2018Article
- Identification of core pathways based on attractor and crosstalk in ischemic stroke.Experimental and therapeutic medicine · 2018Article
- Hyperacute changes in blood mRNA expression profiles of rats after middle cerebral artery occlusion: Towards a stroke time signature.PloS one · 2018Article
- Personalized Analysis by Validation of Monte Carlo for Application of Pathways in Cardioembolic Stroke.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Differential Gene Expression Associated with Meningeal Injury in Acute Mild Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure.International journal of proteomics · 2016Article
- Article
- Sequential expression of cyclooxygenase-2, glutamate receptor-2, and platelet activating factor receptor in rat hippocampal neurons after fluid percussion injury.Neural regeneration research · 2014Article
- Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Decision tree-based method for integrating gene expression, demographic, and clinical data to determine disease endotypes.BMC systems biology · 2013Article
- Phosphodiesterase isoform-specific expression induced by traumatic brain injury.Journal of neurochemistry · 2012Article
- Multiplexed quantification of nucleic acids with large dynamic range using multivolume digital RT-PCR on a rotational SlipChip tested with HIV and hepatitis C viral load.Journal of the American Chemical Society · 2011Article
- Molecular markers and mechanisms of stroke: RNA studies of blood in animals and humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Review
- The role of the blood transcriptome in innate inflammation and stroke.Annals of the New York Academy of Sciences · 2010Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIschemic stroke provokes a systemic inflammatory response. The purpose of this study was to characterize this response on the gene expression level in circulating mononuclear leukocytes from acute ischemic stroke (AIS) patients.
methodsRNA from peripheral blood mononuclear cells (PBMCs) of AIS patients (24 + 2 hours after onset of symptoms) was analyzed with Affymetrix U133A GeneChips using a pooled design. We compared the gene expression signature from AIS patients (n = 20), stroke survivors (n = 15), patients with acute traumatic brain injury (ATBI, n = 15) and healthy control subjects without vascular risk factors (n = 15).
resultsExpression levels of 9682 probe sets with present calls on each GeneChip were compared. Between AIS patients and stroke survivors or between AIS patients and ATBI patients there were no significant differences in expression values of single genes after correction for multiple testing. However, comparison of the PBMC expression profiles from AIS patients and healthy subjects revealed significantly different expression (p = 0.012) of a single probe set, specific for phosphodiesterase 4 D (PDE4D). In order to detect modest expression differences in multiple genes with a presumed cumulative effect we studied the gene expression of functional groups of genes by global statistical tests. Analysis of 11 gene groups revealed differential expression between AIS patients and healthy subjects for genes involved in the inflammatory response (GeneOntology GO:0006954). Genes encoding the N-formyl peptide receptor-like 1 (FPRL1), interleukin-1 receptor antagonist (IL1RN) and complement component 3a receptor 1 (C3AR1) contributed most to the observed difference.
conclusionsThis transcriptome analysis did not identify significant changes between circulating mononuclear cells from AIS patients 24 hours after stroke and closely matched stroke survivors. However, comparing AIS patients with healthy control subjects revealed measurable differences in PDE4D and in inflammatory response genes when considered as a set.
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