ArticlePloS one2008
A high through-put reverse genetic screen identifies two genes involved in remote memory in mice.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Roles of Rac1-Dependent Intrinsic Forgetting in Memory-Related Brain Disorders: Demon or Angel.International journal of molecular sciences · 2023Review
- A missense mutation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Neural, Cellular and Molecular Mechanisms of Active Forgetting.Frontiers in systems neuroscience · 2018Review
- Hippocampal GABANeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Article
- Comparison of inbred mouse substrains reveals segregation of maladaptive fear phenotypes.Frontiers in behavioral neuroscience · 2014Article
- MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Article
- Interdependence of measures in pavlovian conditioned freezing.Neuroscience letters · 2011Article
- Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories.The EMBO journal · 2011Article
- Article
- Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Automated assessment of pavlovian conditioned freezing and shock reactivity in mice using the video freeze system.Frontiers in behavioral neuroscience · 2010Article
- Episodic memory in schizophrenia.Neuropsychology review · 2009Review
- Searching for genes underlying behavior: lessons from circadian rhythms.Science (New York, N.Y.) · 2008Article
- Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?Molecular brain · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have revealed that the initial stages of memory formation require several genes involved in synaptic, transcriptional and translational mechanisms. In contrast, very little is known about the molecular and cellular mechanisms underlying later stages of memory, including remote memory (i.e. 7-day memory). To identify genes required for remote memory, we screened randomly selected mouse strains harboring known mutations. In our primary reverse genetic screen, we identified 4 putative remote memory mutant strains out of a total of 54 lines analyzed. Additionally, we found 11 other mutant strains with other abnormal profiles. Secondary screens confirmed that mutations of integrin beta2 (Itgbeta2) and steryl-O-acyl transferase 1 (Soat1) specifically disrupted remote memory. This study identifies some of the first genes required for remote memory, and suggests that screens of targeted mutants may be an efficient strategy to identify molecular requirements for this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.