ArticleThe Journal of clinical investigation2008
p21Cip1 modulates arterial wound repair through the stromal cell-derived factor-1/CXCR4 axis in mice.
Article in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Platelet factor 4 and stromal cell-derived factor are novel prognostic biomarkers for cerebral vasospasm and mortality after subarachnoid hemorrhage.Scientific reports · 2025Article
- Review
- Mast cell activation and degranulation in acute artery injury: A target for post-operative therapy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Role and implications of the CXCL12/CXCR4/CXCR7 axis in atherosclerosis: still a debate.Annals of medicine · 2021Review
- Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation.Scientific reports · 2021Article
- The immunoregulatory role of p21 in the development of the temporomandibular joint-osteoarthritis.Clinical and experimental dental research · 2021Article
- Correlation between single nucleotide polymorphisms in CXCR4 microRNA binding site and the susceptibility to knee osteoarthritis in Han Chinese population.Journal of clinical laboratory analysis · 2021Article
- Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology.Cellular and molecular life sciences : CMLS · 2021Review
- Foam cells promote atherosclerosis progression by releasing CXCL12.Bioscience reports · 2020Article
- Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1.Journal of experimental & clinical cancer research : CR · 2019Article
- p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.The EMBO journal · 2017Article
- p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation.Arthritis research & therapy · 2015Article
- The Role of Chemokines in Fibrotic Wound Healing.Advances in wound care · 2015Review
- A cellular, molecular, and pharmacological basis for appendage regeneration in mice.Genes & development · 2015Article
- Cyclin‑dependent kinase inhibitor p21 does not impact embryonic endochondral ossification in mice.Molecular medicine reports · 2015Article
- Resveratrol Upregulates Cardiac SDF-1 in Mice with Acute Myocardial Infarction through the Deacetylation of Cardiac p53.PloS one · 2015Article
- Article
- MIF and CXCL12 in Cardiovascular Diseases: Functional Differences and Similarities.Frontiers in immunology · 2015Review
- Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives.Frontiers in immunology · 2015Review
- TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling.Science translational medicine · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Cyclin-dependent kinase inhibitors, including p21Cip1, are implicated in cell turnover and are active players in cardiovascular wound repair. Here, we show that p21Cip1 orchestrates the complex interactions between local vascular and circulating immune cells during vascular wound repair. In response to femoral artery mechanical injury, mice with homozygous deletion of p21Cip1 displayed accelerated proliferation of VSMCs and increased immune cell infiltration. BM transplantation experiments indicated that local p21Cip1 plays a pivotal role in restraining excessive proliferation during vascular wound repair. Increased local vascular stromal cell-derived factor-1 (SDF-1) levels were observed after femoral artery injury in p21+/+ and p21-/- mice, although this was significantly greater in p21-/- animals. In addition, disruption of SDF-1/CXCR4 signaling inhibited the proliferative response during vascular remodeling in both p21+/+ and p21-/- mice. We provide evidence that the JAK/STAT signaling pathway is an important regulator of vascular SDF-1 levels and that p21Cip1 inhibits STAT3 binding to the STAT-binding site within the murine SDF-1 promoter. Collectively, these results suggest that p21Cip1 activity is essential for the regulation of cell proliferation and inflammation after arterial injury in local vascular cells and that the SDF-1/CXCR4 signaling system is a key mediator of vascular proliferation in response to injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.