ArticlePsychopharmacology2008
Effects of chemotherapeutic agents 5-fluorouracil and methotrexate alone and combined in a mouse model of learning and memory.
Article in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cytokines as mediators of chemotherapy-associated cognitive changes: current evidence, limitations and directions for future research.PloS one · 2013Pooled it
- Effects of quercetin and derivatives on NAMPT/Sirtuin-1 metabolic pathway in neuronal cells: an approach to mitigate chemotherapy-induced cognitive impairment.Metabolic brain disease · 2025Article
- Microglia-Mediated Synaptic Dysfunction Contributes to Chemotherapy-Related Cognitive Impairment.Journal of neurochemistry · 2025Article
- Cancer related cognitive impairment: a downside of cancer treatment.Frontiers in oncology · 2024Review
- APurinergic signalling · 2023Article
- The effect of doxorubicin or cyclophosphamide treatment on auditory brainstem response in mice.Experimental brain research · 2022Article
- Animal models of chemotherapy-induced cognitive decline in preclinical drug development.Psychopharmacology · 2021Review
- The Effects of 5-Fluorouracil/Leucovorin Chemotherapy on Cognitive Function in Male Mice.Frontiers in molecular biosciences · 2021Article
- Article
- Development of a Human APOE Knock-in Mouse Model for Study of Cognitive Function After Cancer Chemotherapy.Neurotoxicity research · 2019Article
- Article
- KU32 prevents 5-fluorouracil induced cognitive impairment.Behavioural brain research · 2017Article
- Article
- Clavulanic acid enhances glutamate transporter subtype I (GLT-1) expression and decreases reinforcing efficacy of cocaine in mice.Amino acids · 2016Article
- Potential Use of Nicotinic Receptor Agonists for the Treatment of Chemotherapy-Induced Cognitive Deficits.Neurochemical research · 2015Review
- Cognitive impact of cytotoxic agents in mice.Psychopharmacology · 2015Article
- Higher cardiorespiratory fitness levels are associated with greater hippocampal volume in breast cancer survivors.Frontiers in human neuroscience · 2015Article
- Consequences of cancer treatments on adult hippocampal neurogenesis: implications for cognitive function and depressive symptoms.Neuro-oncology · 2014Review
- The impact of sustained and intermittent docetaxel chemotherapy regimens on cognition and neural morphology in healthy mice.Psychopharmacology · 2014Article
- Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy.British journal of pharmacology · 2014Article
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Authors and funding
3 authors.
Funding
Abstract
rationaleThe concern that adjuvant cancer chemotherapy agents cause cognitive impairment in a significant number of patients has been expressed by patients and healthcare providers, but clinical studies have yielded conflicting results to date.
objectiveWe directly tested two commonly used chemotherapeutic agents in a mouse model of learning and memory. MATERIALS AND
methodsIn the present study, mice were conditioned to respond for a liquid reinforcer (Ensure solution) in the presence of an audible tone on day 1 as a measure of acquisition and were then required to perform the same response on day 2 as a measure of retrieval and retention. Methotrexate and 5-fluorouracil were administered prior to the day 1 session.
resultsMethotrexate (1.0-32 mg/kg) alone failed to alter mean latency acquisition, retrieval, or reinforced response rates. Similar to scopolamine, a known amnesic in this assay, 5-fluorouracil (3-75 mg/kg) failed to alter response rates or acquisition latency on day 1 but significantly altered latency to retrieve a previously learned response on day 2. In combination, 3.2 mg/kg methotrexate plus 75 mg/kg 5-fluorouracil significantly increased day 1 and day 2 acquisition and retrieval latencies without altering response rates or motivation to respond as measured by progressive ratio responding.
conclusionTaken together, these data demonstrate that 5-fluorouracil causes increased latencies for retrieval of previously learned behavioral responses and that combination of chemotherapeutic agents may produce greater delays than either agent alone, including when neither agent alone does so.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.