Trial reportDer Anaesthesist2008
[Antibiotic treatment of surgical intensive care patients: procalcitonin to guide duration of therapy].
Trial report in Der Anaesthesist, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Procalcitonin-guided antibiotic therapy in critically ill adults: a meta-analysis.BMC infectious diseases · 2017Pooled it
- Meta-analysis and systematic review of procalcitonin-guided therapy in respiratory tract infections.Antimicrobial agents and chemotherapy · 2011Pooled it
- Effect of procalcitonin-guided treatment in patients with infections: a systematic review and meta-analysis.Infection · 2009Pooled it
- Trial
- [Procalcitonin as a tool for the assessment of successful therapy of severe sepsis : An analysis using clinical routine data].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2018Review
- Update on procalcitonin measurements.Annals of laboratory medicine · 2014Review
- [Diagnostic markers and assessment of efficacy of antibacterial therapy].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2014Review
- [Procalcitonin-based algorithm. Management of antibiotic therapy in critically ill patients].Der Anaesthesist · 2011Review
- When once is not enough--further evidence of procalcitonin-guided antibiotic stewardship.Critical care (London, England) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of resistance by infective bacterial species is an incentive to reconsider the indications and administration of available antibiotics. Correct recognition of the indications and duration of therapy are particularly important for the use of highly potent substances in the intensive care situation. There has as yet been no clinical chemical parameter which is capable of specifically distinguishing a bacterial infection from a viral or non-infectious inflammatory reaction, but it now appears that procalcitonin (PCT) offers this possibility. The present study was intended to clarify whether PCT can be used to guide antibiotic therapy in surgical intensive care patients. A total of 110 patients in a surgical intensive care ward receiving antibiotic therapy after confirmed infection or a high grade suspicion of infection were enrolled in this study. In 57 of these patients a new decision was reached each day as to whether the antibiotic therapy should be continued after daily PCT determination and clinical assessment. The control group consisted of 53 patients with a standardized duration of antibiotic therapy over 8 days. Demographic and clinical data were comparable in both groups. However, in the PCT group the duration of antibiotic therapy was significantly shorter compared to controls (5.9+/-1.7 vs. 7.9+/-0.5 days, p<0.001) without unfavorable effects on clinical outcome.
Indexed as
Identifiers
18463831What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.