ArticleInternational journal of biological sciences2008
Association between the frequency of class II HLA antigens and the susceptibility to intrauterine infection of hepatitis B virus.
Article in International journal of biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- High resolution HLA-DRB1 analysis and shared molecular amino acid signature of DRβ1 molecules in Occult hepatitis B infection.BMC immunology · 2022Article
- Host Genetic Determinants of Hepatitis B Virus Infection.Frontiers in genetics · 2019Review
- Genetic variant in CXCL13 gene is associated with susceptibility to intrauterine infection of hepatitis B virus.Scientific reports · 2016Article
- Clinical Relevance of HLA Gene Variants in HBV Infection.Journal of immunology research · 2016Review
- Evaluation of neonatal Toll-like receptors 3 (c.1377C/T) and 9 (G2848A) gene polymorphisms in HBV intrauterine transmission susceptibility.Epidemiology and infection · 2015Article
- Association between single-nucleotide polymorphisms and early spontaneous hepatitis B virus e antigen seroconversion in children.BMC research notes · 2014Article
- Association of human leukocyte antigen class I polymorphism with spontaneous clearance of hepatitis B surface antigen in Qidong Han population.Clinical & developmental immunology · 2013Article
- Hepatitis B Virus Infection during Pregnancy: Transmission and Prevention.Middle East journal of digestive diseases · 2011Review
- Molecular characteristics and stages of chronic hepatitis B virus infection.World journal of gastroenterology · 2009Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple factors determine the susceptibility to intrauterine hepatitis B virus (HBV) infection. These factors include the HBV structure, HBV mutation, HBV DNA level, placental barrier, the immune status of the mother, and the genetic make-ups of the newborn infants. Since HLA system is an integral component of the immune response, we hypothesized that the highly polymorphic HLA genes are the key determinants of intrauterine HBV infection. In this study, we selected newborn infants of HBsAg-positive mothers, and divided the infants into 2 groups: intrauterine infection group and non-intrauterine infection group according to the status whether or not they were infected at birth. Each infected infant was compared with 2 controls from the same birth cohort. HLA-DR allele typing was performed using a PCR-sequence specific primer (PCR-SSP) for 24 subjects with intrauterine infection and 48 controls without infection. We found that, among the fifteen (15) HLA-DR alleles assessed, HLA-DRB1*07 was the one, and the only one, significantly in excess (OR = 6.66, P = 0.004) in the intrauterine infection group compared to the non-intrauterine infection group. Our findings thus suggest that high frequency of HLA class II molecules, e.g. HLA-DRB1*07, is associated with the susceptibility of the infants to intrauterine HBV infection.
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