ArticleInternational journal of biological sciences2008
Comparative understanding of UTS2 and UTS2R genes for their involvement in type 2 diabetes mellitus.
Article in International journal of biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 52 citations in OpenAlex.
- Sex-biased gene regulation varies across human populations as a result of adaptive evolution.American journal of biological anthropology · 2024Article
- Combination of Docking-Based and Pharmacophore-Based Virtual Screening Identifies Novel Agonists That Target the Urotensin Receptor.Molecules (Basel, Switzerland) · 2022Article
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- The Role of Urotensin-II in Obesity and Metabolic Syndrome in Pediatric Population.Children (Basel, Switzerland) · 2022Article
- Association of resistin (rs3745367) and urotensin II (rs228648 and rs2890565) gene polymorphisms with risk of type 2 diabetes mellitus in Indian population.Molecular biology reports · 2020Article
- Chronic Urotensin-II Administration Improves Whole-Body Glucose Tolerance in High-Fat Diet-Fed Mice.Frontiers in endocrinology · 2019Article
- Haplotypes in the promoter region of the CIDEC gene associated with growth traits in Nanyang cattle.Scientific reports · 2015Article
- A closer look at the role of urotensin II in the metabolic syndrome.Frontiers in endocrinology · 2012Article
- Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.PloS one · 2011Article
- Whole-genome resequencing shows numerous genes with nonsynonymous SNPs in the Japanese native cattle Kuchinoshima-Ushi.BMC genomics · 2011Article
- The heparan and heparin metabolism pathway is involved in regulation of fatty acid composition.International journal of biological sciences · 2011Article
- Article
- Discovery of novel genetic networks associated with 19 economically important traits in beef cattle.International journal of biological sciences · 2009Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Several reports have shown that urotensin 2 (UTS2) and its receptor (UTS2R) are involved in glucose metabolism and insulin resistance, which lead to development of type 2 diabetes mellitus (T2DM) in humans. In the present study, we annotated both bovine UTS2 and UTS2R genes and identified 5 single nucleotide polymorphisms (SNPs) for the former gene and 14 mutations for the latter gene. Four mutations were genotyped on a Wagyu x Limousin reference population, including 6 F(1 )bulls, 113 F(1 )dams and ~250 F(2 )progeny. Among 12 phenotypes related to fat deposition and fatty acid composition, we observed that the UTS2 gene was significantly associated with the amount of skeletal saturated fatty acids, while its receptor (UTS2R) gene had significant effects on amounts of saturated and monounsaturated fatty acids, Delta(9) desaturase activity for converting 16:0 into 16:1, muscle fat (marbling) score and Longissimus Dorsi muscle area. However, in this population, these markers were not associated with subcutaneous fat depth or percent kidney, pelvic and heart fat. We also found that mutations in the promoter regions altered the promoter activities in both genes and coding SNPs might affect the mRNA stability in the UTS2R gene. Overall, our present study provides the first evidence that both UTS2 and UTS2R genes regulate skeletal muscle fat accumulation and fatty acid metabolism, thus indicating their potential pathological functions related to obesity and T2DM in humans.
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