ArticlePLoS computational biology2008
Systematic analysis of pleiotropy in C. elegans early embryogenesis.
Article in PLoS computational biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Pleiotropic germline PTEN mutations influence gastrulation through dysregulated AKT activation.NPJ genomic medicine · 2026Article
- Cell atlases and the developmental foundations of the phenotype.PLoS computational biology · 2026Article
- Article
- Pleiotropy drives evolutionary repair of the responsiveness of polarized cell growth to environmental cues.Frontiers in microbiology · 2023Article
- A network view of human immune system and virus-human interaction.Frontiers in immunology · 2022Article
- Transcriptome Analysis of Maternal Gene Transcripts in Unfertilized Eggs ofInternational journal of molecular sciences · 2020Article
- Why does allometry evolve so slowly?Integrative and comparative biology · 2019Article
- Article
- Landscape of Pleiotropic Proteins Causing Human Disease: Structural and System Biology Insights.Human mutation · 2017Article
- Body maps on the human genome.Molecular cytogenetics · 2013Article
- The many faces of pleiotropy.Trends in genetics : TIG · 2013Article
- Aquatic models, genomics and chemical risk management.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2012Article
- GeBP/GPL transcription factors regulate a subset of CPR5-dependent processes.Plant physiology · 2011Article
- Inferring pleiotropy by network analysis: linked diseases in the human PPI network.BMC systems biology · 2011Article
- Whole-animal imaging, gene function, and the Zebrafish Phenome Project.Current opinion in genetics & development · 2011Review
- PRIMe: a method for characterization and evaluation of pleiotropic regions from multiple genome-wide association studies.Bioinformatics (Oxford, England) · 2011Article
- Information flow analysis of interactome networks.PLoS computational biology · 2009Article
- Information-based methods for predicting gene function from systematic gene knock-downs.BMC bioinformatics · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Pleiotropy refers to the phenomenon in which a single gene controls several distinct, and seemingly unrelated, phenotypic effects. We use C. elegans early embryogenesis as a model to conduct systematic studies of pleiotropy. We analyze high-throughput RNA interference (RNAi) data from C. elegans and identify "phenotypic signatures", which are sets of cellular defects indicative of certain biological functions. By matching phenotypic profiles to our identified signatures, we assign genes with complex phenotypic profiles to multiple functional classes. Overall, we observe that pleiotropy occurs extensively among genes involved in early embryogenesis, and a small proportion of these genes are highly pleiotropic. We hypothesize that genes involved in early embryogenesis are organized into partially overlapping functional modules, and that pleiotropic genes represent "connectors" between these modules. In support of this hypothesis, we find that highly pleiotropic genes tend to reside in central positions in protein-protein interaction networks, suggesting that pleiotropic genes act as connecting points between different protein complexes or pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.