ArticleAmerican journal of physiology. Renal physiology2008
VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation.
Article in American journal of physiology. Renal physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Signaling pathways related to interstitial cystitis.Frontiers in immunology · 2026Review
- Pharmacogenetic inhibition of lumbosacral sensory neurons alleviates visceral hypersensitivity in a mouse model of chronic pelvic pain.PloS one · 2022Article
- Transient receptor potential vanilloid type 4 (TRPV4) in urinary bladder structure and function.Current topics in membranes · 2022Review
- Single-cell transcriptomics of murine mural cells reveals cellular heterogeneity.Science China. Life sciences · 2021Article
- Candidate Biomarkers for Specific Intraoperative Near-Infrared Imaging of Soft Tissue Sarcomas: A Systematic Review.Cancers · 2021Review
- Functional effects of blocking VEGF/VEGFR2 signaling in the rat urinary bladder in acute and chronic CYP-induced cystitis.American journal of physiology. Renal physiology · 2019Article
- Role of neurogenic inflammation in local communication in the visceral mucosa.Seminars in immunopathology · 2018Review
- Inflammation and Tissue Remodeling in the Bladder and Urethra in Feline Interstitial Cystitis.Frontiers in systems neuroscience · 2018Article
- Effect of VEGF on Inflammatory Regulation, Neural Survival, and Functional Improvement in Rats following a Complete Spinal Cord Transection.Frontiers in cellular neuroscience · 2017Article
- Effects of CYP-Induced Cystitis on Growth Factors and Associated Receptor Expression in Micturition Pathways in Mice with Chronic Overexpression of NGF in Urothelium.Journal of molecular neuroscience : MN · 2016Article
- Advances in intravesical therapy for urinary tract disorders.Expert opinion on drug delivery · 2016Review
- Angiogenic factors, bladder neuroplasticity and interstitial cystitis-new pathobiological insights.Translational andrology and urology · 2015Review
- Biomarkers of Angiogenesis in Colorectal Cancer.Biomarkers in cancer · 2015Review
- Imaging VEGF receptor expression to identify accelerated atherosclerosis.EJNMMI research · 2014Article
- VEGF induces sensory and motor peripheral plasticity, alters bladder function, and promotes visceral sensitivity.BMC physiology · 2012Article
- Increased smooth muscle contractility in mice deficient for neuropilin 2.The American journal of pathology · 2012Article
- Neuropilins: expression and roles in the epithelium.International journal of experimental pathology · 2012Review
- Mathematical model of tumor immunotherapy for bladder carcinoma identifies the limitations of the innate immune response.Oncoimmunology · 2012Article
- In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model.Molecular imaging and biology · 2011Article
- VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG.BMC physiology · 2011Article
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
Recent evidence supports a role for vascular endothelium growth factor (VEGF) signaling in bladder inflammation. However, it is not clear what bladder cells are targeted by VEGF. Therefore, we determined the nature of cells responding to VEGF in normal and inflamed bladders by tagging such cells in vivo with a targeted fluorescent tracer, scVEGF/Cy, an engineered single-chain VEGF labeled with Cy5.5 dye, which identifies cells with accessible and functionally active VEGF receptors. Inflammation was induced by intravesical instillation of PAR-activating peptides or BCG. In vivo NIRF imaging with intravenously injected scVEGF/Cy revealed accumulation of the tracer in the control mouse bladder and established that inflammation increased the steady-state levels of tracer uptake. Ex vivo colocalization of Cy5.5 dye revealed that in normal and at a higher level in inflamed bladder, accumulation of scVEGF/Cy occurs in both urothelial and ganglial cells, expressing VEGF receptors VEGFR-1 and VEGFR-2, as well as VEGF coreceptors neuropilins (NRP) NRP1 and NRP2. PCR results indicate that the messages for VEGF-Rs and NRPs are present in the bladder mucosa and ChIP/QPCR analysis indicated that inflammation induced upregulation of genes encoding VEGFRs and NRPs. Our results strongly suggest new and blossoming VEGF-driven processes in bladder urothelial cells and ganglia in the course of inflammation. We expect that molecular imaging of the VEGF pathway in the urinary tract by receptor-mediated cell tagging in vivo will be useful for clinical diagnosis and therapeutic monitoring, and will help to accelerate the development of bladder-targeting drugs and treatments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.