ArticleGenome research2008
Origin of INSL3-mediated testicular descent in therian mammals.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Identification of key genes related to unilateral cryptorchidism in sheep by comprehensive transcriptomics and proteomics analyses.BMC genomics · 2025Article
- Unearthing the secrets of Australia's most enigmatic and cryptic mammal, the marsupial mole.Science advances · 2025Article
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- Therian origin of INSL3/RXFP2-driven testicular descent in mammals.Frontiers in cell and developmental biology · 2024Article
- Impact of germ cell ablation on the activation of the brain-pituitary-gonadal axis in precocious Atlantic salmon (Salmo salar L.) males.Molecular reproduction and development · 2022Article
- Species-specific partial gene duplication in Arabidopsis thaliana evolved novel phenotypic effects on morphological traits under strong positive selection.The Plant cell · 2022Article
- Comparative Genomic Characterization of Relaxin Peptide Family in Cattle and Buffalo.BioMed research international · 2022Article
- Signatures of Selection for Environmental Adaptation and Zebu × Taurine Hybrid Fitness in East African Shorthorn Zebu.Frontiers in genetics · 2017Article
- Evolutionary Fates and Dynamic Functionalization of Young Duplicate Genes in Arabidopsis Genomes.Plant physiology · 2016Article
- The life history of retrocopies illuminates the evolution of new mammalian genes.Genome research · 2016Article
- Signatures of positive selection in East African Shorthorn Zebu: A genome-wide single nucleotide polymorphism analysis.Scientific reports · 2015Article
- Evolution of the relaxin/insulin-like gene family in anthropoid primates.Genome biology and evolution · 2014Article
- New genes as drivers of phenotypic evolution.Nature reviews. Genetics · 2013Review
- New gene evolution: little did we know.Annual review of genetics · 2013Review
- INSL4 pseudogenes help define the relaxin family repertoire in the common ancestor of placental mammals.Journal of molecular evolution · 2012Article
- Gene duplication and positive selection explains unusual physiological roles of the relaxin gene in the European rabbit.Journal of molecular evolution · 2012Article
- New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts.International journal of evolutionary biology · 2012Article
- Article
- Evolution of the relaxin/insulin-like gene family in placental mammals: implications for its early evolution.Journal of molecular evolution · 2011Article
- INSL3 in the ruminant: a powerful indicator of gender- and genetic-specific feto-maternal dialogue.PloS one · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Testicular descent is a unique physiological adaptation found in therian mammals allowing optimal spermatogenesis below core body temperature. Recent studies show that INSL3, produced by Leydig cells, and its receptor LGR8 (RXFP2) are essential for mediating the transabdominal phase of testicular descent during early development. However, the origin and genetic basis for this physiological adaptation is not clear. Using syntenic mapping and the functional characterization of contemporary and resurrected relaxin family hormones, we show that derivation of INSL3-mediated testicular descent involved the duplication of an ancestral RLN3-like gene that encodes an indiscriminate ligand for LGR7 (RXFP1) and LGR8. This event was followed by acquisition of the LGR7-selective characteristics by a daughter gene (RLN3) prior to the evolution of the common ancestor of monotremes, marsupials, and placentals. A subsequent mutation of the other daughter gene (INSL3) occurred before the emergence of therian mammals, which then led to the derivation of the reciprocal LGR8-specific characteristics of INSL3. The stepwise evolution of these independent signaling pathways through gene duplication and subsequent divergence is consistent with Darwinian theory of selection and adaptation, and the temporal proximity suggests an association between these genetic events and the concurrent evolution of testicular descent in ancestral therian mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.