ArticleJournal of clinical microbiology2008
Epidemiology of severe Streptococcus pyogenes disease in Europe.
Article in Journal of clinical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 6 of them syntheses that pooled it.
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Who cites it
152 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Outcomes and management of pregnancy and puerperal group A streptococcal infections: A systematic review.Acta obstetricia et gynecologica Scandinavica · 2023Pooled it
- Invasive group A streptococcal disease in pregnant women and young children: a systematic review and meta-analysis.The Lancet. Infectious diseases · 2022Pooled it
- Interventions for necrotizing soft tissue infections in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Integration of Genomic and Other Epidemiologic Data to Investigate and Control a Cross-Institutional Outbreak of Streptococcus pyogenes.Emerging infectious diseases · 2016Pooled it
- Linezolid versus vancomycin for skin and soft tissue infections.The Cochrane database of systematic reviews · 2016Pooled it
- Chinese herbal medicines for treating skin and soft-tissue infections.The Cochrane database of systematic reviews · 2014Pooled it
- Predominance of M1European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Invasive group A streptococcal infections requiring paediatric intensive care in children and adolescents: a nationwide retrospective cohort study in Austria.European journal of pediatrics · 2026Observational
- A Minor Sports Injury with Major Consequences: Probable Streptococcal Toxic Shock Syndrome and Necrotizing Soft Tissue Infection in a Young Adult-A Case Report.Reports (MDPI) · 2026Article
- Burden of invasive group a streptococcus infection in Australia: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Strawberry Tongue due to Streptococcal Toxic Shock Syndrome.Clinical case reports · 2026Article
- Usefulness and Description of the Test Puncture Method for Necrotizing Fasciitis Caused by Group A β-HemolyticJournal of plastic and reconstructive surgery · 2026Article
- Reconstructive, functional and psychological outcomes in invasive group A streptococcal soft tissue infections: a 10-year retrospective cohort study 2013-2022.BMC infectious diseases · 2026Article
- Necrotising Soft Tissue Infections: A Single Center's Case Series.International wound journal · 2026Article
- Group A Streptococcus Meningitis, United States, 1997-2022.Emerging infectious diseases · 2026Article
- Fulminant streptococcal toxic shock syndrome presenting as cervical epidural abscess: a case report.Journal of Yeungnam medical science · 2026Article
- <italic>Streptococcus pyogenes</italic> Infection and CD4Journal of innate immunity · 2026Article
- Evidence for early circulation of the M1UK sublineage of Streptococcus pyogenes in Germany, 2015-2023.Emerging microbes & infections · 2025Article
- Invasive Group A Streptococcus infections in children during the post-pandemic period: results from a multicenter study in Italy.Italian journal of pediatrics · 2025Observational
- A case of suspected transmission of group A Streptococcus from a dead body with streptococcal toxic shock syndrome to an autopsy worker.International journal of legal medicine · 2025Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The past 2 decades have brought worrying increases in severe Streptococcus pyogenes diseases globally. To investigate and compare the epidemiological patterns of these diseases within Europe, data were collected through a European Union FP-5-funded program (Strep-EURO). Prospective population-based surveillance of severe S. pyogenes infection diagnosed during 2003 and 2004 was undertaken in 11 countries across Europe (Cyprus, the Czech Republic, Denmark, Finland, France, Germany, Greece, Italy, Romania, Sweden, and the United Kingdom) using a standardized case definition. A total of 5,522 cases were identified across the 11 countries during this period. Rates of reported infection varied, reaching 3/100,000 population in the northern European countries. Seasonal patterns of infection showed remarkable congruence between countries. The risk of infection was highest among the elderly, and rates were higher in males than in females in most countries. Skin lesions/wounds were the most common predisposing factor, reported in 25% of cases; 21% had no predisposing factors reported. Skin and soft tissue were the most common foci of infection, with 32% of patients having cellulitis and 8% necrotizing fasciitis. The overall 7-day case fatality rate was 19%; it was 44% among patients who developed streptococcal toxic shock syndrome. The findings from Strep-EURO confirm a high incidence of severe S. pyogenes disease in Europe. Furthermore, these results have identified targets for public health intervention, as well as raising awareness of severe S. pyogenes disease across Europe.
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