ArticleJournal of neurophysiology2008
Early postnatal development of reciprocal Ia inhibition in the murine spinal cord.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
- KCC2 enhancers normalize reflex responses and improve locomotor function after chronic spinal cord injury.The Journal of physiology · 2025Article
- Synaptic imbalance and increased inhibition impair motor function in SMA.Science advances · 2025Article
- ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal α-motoneurons.EMBO reports · 2023Article
- In vitro longitudinal lumbar spinal cord preparations to study sensory and recurrent motor microcircuits of juvenile mice.Journal of neurophysiology · 2022Article
- The Dorsal Root Ganglion as a Novel Neuromodulatory Target to Evoke Strong and Reproducible Motor Responses in Chronic Motor Complete Spinal Cord Injury: A Case Series of Five Patients.Neuromodulation : journal of the International Neuromodulation Society · 2021Article
- How to Identify Responders and Nonresponders to Dorsal Root Ganglion-Stimulation Aimed at Eliciting Motor Responses in Chronic Spinal Cord Injury: Post Hoc Clinical and Neurophysiological Tests in a Case Series of Five Patients.Neuromodulation : journal of the International Neuromodulation Society · 2021Article
- Facilitation of antagonist motor output through short-latency sensory pathways during postnatal development in the mouse.Neuroscience letters · 2018Article
- Ankle muscle tenotomy does not alter ankle flexor muscle recruitment bias during locomotor-related repetitive limb movement in late-stage chick embryos.Developmental psychobiology · 2018Article
- Decoding the organization of spinal circuits that control locomotion.Nature reviews. Neuroscience · 2016Review
- A Review on Locomotor Training after Spinal Cord Injury: Reorganization of Spinal Neuronal Circuits and Recovery of Motor Function.Neural plasticity · 2016Review
- A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements.eLife · 2015Article
- Contribution of the potassium-chloride cotransporter KCC2 to the strength of inhibition in the neonatal rodent spinal cord in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Molecular and cellular development of spinal cord locomotor circuitry.Frontiers in molecular neuroscience · 2015Review
- Characterization of long descending premotor propriospinal neurons in the spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Inhibition downunder: an update from the spinal cord.Current opinion in neurobiology · 2014Review
- V1 and v2b interneurons secure the alternating flexor-extensor motor activity mice require for limbed locomotion.Neuron · 2014Article
- Spontaneous locomotor activity in late-stage chicken embryos is modified by stretch of leg muscles.The Journal of experimental biology · 2014Article
- Circuits for grasping: spinal dI3 interneurons mediate cutaneous control of motor behavior.Neuron · 2013Article
- Early postnatal development of GABAergic presynaptic inhibition of Ia proprioceptive afferent connections in mouse spinal cord.Journal of neurophysiology · 2013Article
- Requirement of neuronal connexin36 in pathways mediating presynaptic inhibition of primary afferents in functionally mature mouse spinal cord.The Journal of physiology · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The pathway mediating reciprocal inhibition from muscle spindle afferents (Ia axons) to motoneurons (MNs) supplying antagonist muscles has been well studied in adult cats, but little is known about how this disynaptic pathway develops. As a basis for studying its development, we characterized this pathway in mice during the first postnatal week, focusing on the projection of quadriceps (Q) Ia axons to posterior biceps-semitendinosis (PBSt) MNs via Ia inhibitory interneurons. Synaptic potentials in PBSt MNs evoked by Q nerve stimulation are mediated disynaptically and are blocked by strychnine, implying that glycine is the major inhibitory transmitter as in adult cats. The specificity of neuronal connections in this reflex pathway is already high at birth; Q afferents evoke inhibitory synaptic potentials in PBSt MNs, but afferents supplying the adductor muscle do not. Similar to this disynaptic pathway in cats, Renshaw cells inhibit the interposed Ia interneurons, as they reduce the disynaptic input from Q axons but do not inhibit PBSt MNs directly. Reciprocal inhibition functionally inhibits the monosynaptic excitatory reflex in PBSt MNs by P3, but this functional inhibition is weak at P1. Finally, deletion of the transcription factor Pax6, which is required for the development of V1-derived Renshaw cells, does not block development of this pathway. This suggests either that Pax6 is not required for the phenotypic development of all V1-derived spinal interneurons or that these inhibitory interneurons are not derived from V1 precursors.
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