ArticleJournal of neuroimmunology2008
Interleukin-1beta affects calcium signaling and in vitro cell migration of astrocyte progenitors.
Article in Journal of neuroimmunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Microglia and immune signaling as architects of the brain.Frontiers in cellular neuroscience · 2026Review
- The role of maternal infections in neurodevelopmental psychiatric disorders: focus on the P2X7/NLRP3/IL-1β signalling pathway.Journal of neuroinflammation · 2025Review
- miR-21 Expressed by Dermal Fibroblasts Enhances Skin Wound Healing Through the Regulation of Inflammatory Cytokine Expression.Inflammation · 2024Article
- Connexins in Astrocyte Migration.Frontiers in pharmacology · 2019Review
- ATP-induced CaCellular and molecular life sciences : CMLS · 2017Review
- Interleukin-1 beta guides the migration of cortical neurons.Journal of neuroinflammation · 2014Article
- Surveillance, phagocytosis, and inflammation: how never-resting microglia influence adult hippocampal neurogenesis.Neural plasticity · 2014Review
- Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1.Journal of neuroinflammation · 2012Article
- P2Y receptors on astrocytes and microglia mediate opposite effects in astroglial proliferation.Purinergic signalling · 2011Article
- Targeting pannexin1 improves seizure outcome.PloS one · 2011Article
- Astrocyte-derived tissue transglutaminase interacts with fibronectin: a role in astrocyte adhesion and migration?PloS one · 2011Article
- The carboxyl-terminal domain of connexin43 is a negative modulator of neuronal differentiation.The Journal of biological chemistry · 2010Article
- Cell migration in the normal and pathological postnatal mammalian brain.Progress in neurobiology · 2009Review
- Point mutation in the mouse P2X7 receptor affects intercellular calcium waves in astrocytes.ASN neuro · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Spontaneous calcium activity of neural progenitors is largely dependent on a paracrine signaling mechanism involving release of ATP and activation of purinergic receptors. Although it is well documented that, in mature astrocytes, cytokines modulate the expression levels of certain purinergic receptors, nothing is known about their impact during early stages of development. Here we provide evidence that conditioned medium from activated microglia and interleukin-1beta, but not tumor necrosis factor-alpha, decrease the frequency of calcium oscillations and reduce the rate of in vitro migration of astrocyte progenitors. Such alterations were due to changes in activity of two purinergic P2 receptors, and not to the amount of released ATP. These results indicate that interleukin-1beta plays an important role during early stages of CNS development, modulating calcium signaling and cell migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.