ArticlePlacenta2008
Circulating and placental endoglin concentrations in pregnancies complicated by intrauterine growth restriction and preeclampsia.
Article in Placenta, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 74 citations in OpenAlex.
- Circulating EGFL7 distinguishes between IUGR and PE: an observational case-control study.Scientific reports · 2021Observational
- Clinical Presentation of Preeclampsia and the Diagnostic Value of Proteins and Their Methylation Products as Biomarkers in Pregnant Women with Preeclampsia and Their Newborns.Journal of pregnancy · 2018Review
- Circulating Maternal Total Cell-Free DNA, Cell-Free Fetal DNA and Soluble Endoglin Levels in Preeclampsia: Predictors of Adverse Fetal Outcome? A Cohort Study.Molecular diagnosis & therapy · 2016Article
- Relationship of Liver X Receptors α and Endoglin Levels in Serum and Placenta with Preeclampsia.PloS one · 2016Article
- Response to Plasmapheresis Measured by Angiogenic Factors in a Woman with Antiphospholipid Syndrome in Pregnancy.Case reports in obstetrics and gynecology · 2015Article
- Transforming growth factor β signaling in uterine development and function.Journal of animal science and biotechnology · 2014Review
- The expression and characterization of endoglin in uterine leiomyosarcoma.Clinical & experimental metastasis · 2013Article
- Evidence of an imbalance of angiogenic/antiangiogenic factors in massive perivillous fibrin deposition (maternal floor infarction): a placental lesion associated with recurrent miscarriage and fetal death.American journal of obstetrics and gynecology · 2013Article
- Effects of hypoxia inducible factors-1α on autophagy and invasion of trophoblasts.Clinical and experimental reproductive medicine · 2012Article
- Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction.Reproductive biology and endocrinology : RB&E · 2011Article
- Biochemical markers for prediction of preclampsia: review of the literature.Journal of prenatal medicine · 2011Article
- Glyceryl trinitrate inhibits hypoxia-induced release of soluble fms-like tyrosine kinase-1 and endoglin from placental tissues.The American journal of pathology · 2011Article
- Midpregnancy levels of angiogenic markers in relation to maternal characteristics.American journal of obstetrics and gynecology · 2011Article
- Angiogenic factors and preeclampsia.Seminars in nephrology · 2011Review
- Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: possible implications for preeclampsia and intrauterine growth restriction.The American journal of pathology · 2010Article
- Potential markers of preeclampsia--a review.Reproductive biology and endocrinology : RB&E · 2009Review
- Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression.Hypertension (Dallas, Tex. : 1979) · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Inadequate trophoblast invasion and spiral artery remodeling leading to poor placental perfusion and hypoxia are believed to underlie preeclampsia (PE) and intrauterine growth restriction (IUGR). Recent studies implicate increased circulating endoglin as a contributor to the pathogenesis of PE. The objective of this study was to determine whether placental and circulating endoglin concentrations are altered in pregnancies complicated by intrauterine growth restricted (IUGR) infants and to address the role of hypoxia on the regulation of placental endoglin. We analyzed 10 placentas each from normal pregnant (NP), PE, and IUGR subjects. Endoglin levels were 2.5-fold higher in preeclamptic placentas compared to NP (15.4+/-2.6 versus 5.7+/-1.0, p<0.01). In contrast, endoglin levels were similar in NP and IUGR placentas (5.7+/-1.0 vs 5.9+/-1.1, p=NS). Placentas from pregnancies with both PE and IUGR exhibited endoglin levels comparable to the PE group and significantly different from normotensive pregnancies with and without IUGR pregnancies (mean 14.9+/-4.0, n=9, p=0.013). Soluble endoglin concentrations in maternal plasma were comparable in NP and IUGR, but higher in women with PE (n=10 per group, p<0.05). Despite a 2-fold increase in hypoxia inducible factor, HIF-1alpha, we did not observe endoglin upregulation in NP, PE, or IUGR placental villous explants exposed to hypoxia (2% oxygen). In contrast to PE, placental or circulating endoglin is not increased in normotensive women delivering small, asymmetrically grown (IUGR) infants at term. The placentas of women with IUGR appear to be fundamentally different from PE women with respect to endoglin, despite the proposed common pathology of deficient trophoblast invasion/spiral artery remodeling and poor placental perfusion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.