ArticleJournal of nanobiotechnology2008
Cationic nanoparticles for delivery of amphotericin B: preparation, characterization and activity in vitro.
Article in Journal of nanobiotechnology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Colloidal Dispersions of Gramicidin D in Water: Preparation, Characterization, and Differential Cytotoxicity.ACS omega · 2025Article
- Emerging Cationic Nanovaccines.Pharmaceutics · 2024Review
- Transient Coatings from Nanoparticles Achieving Broad-Spectrum and High Antimicrobial Performance.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Supramolecular Nanostructures for Vaccines.Biomimetics (Basel, Switzerland) · 2021Review
- Antimicrobial Polymer-Based Assemblies: A Review.International journal of molecular sciences · 2021Review
- Cationic Nanostructures for Vaccines Design.Biomimetics (Basel, Switzerland) · 2020Review
- Hybrid Nanoparticles of Poly (Methyl Methacrylate) and Antimicrobial Quaternary Ammonium Surfactants.Pharmaceutics · 2020Article
- Simple Nanoparticles from the Assembly of Cationic Polymer and Antigen as Immunoadjuvants.Vaccines · 2020Article
- Antimicrobial Coatings from Hybrid Nanoparticles of Biocompatible and Antimicrobial Polymers.International journal of molecular sciences · 2018Article
- Self-Assembled Antimicrobial Nanomaterials.International journal of environmental research and public health · 2018Review
- Cationic Biomimetic Particles of Polystyrene/Cationic Bilayer/Gramicidin for Optimal Bactericidal Activity.Nanomaterials (Basel, Switzerland) · 2017Article
- Synthesis, characterization, and in vitro activity againstNanotechnology, science and applications · 2017Article
- Antifungal Therapy for Systemic Mycosis and the Nanobiotechnology Era: Improving Efficacy, Biodistribution and Toxicity.Frontiers in microbiology · 2017Review
- Lysine-functionalized nanodiamonds as gene carriers: development of stable colloidal dispersion for in vitro cellular uptake studies and siRNA delivery application.International journal of nanomedicine · 2016Article
- The antimicrobial activity of free and immobilized poly (diallyldimethylammonium) chloride in nanoparticles of poly (methylmethacrylate).Journal of nanobiotechnology · 2015Article
- Supramolecular cationic assemblies against multidrug-resistant microorganisms: activity and mechanism of action.International journal of molecular sciences · 2015Article
- Cationic liposomal sodium stibogluconate (SSG), a potent therapeutic tool for treatment of infection by SSG-sensitive and -resistant Leishmania donovani.Antimicrobial agents and chemotherapy · 2015Article
- Significance of algal polymer in designing amphotericin B nanoparticles.TheScientificWorldJournal · 2014Article
- Cationic antimicrobial polymers and their assemblies.International journal of molecular sciences · 2013Review
- Biomimetic nanoparticles: preparation, characterization and biomedical applications.International journal of nanomedicine · 2010Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParticulate systems are well known to be able to deliver drugs with high efficiency and fewer adverse side effects, possibly by endocytosis of the drug carriers. On the other hand, cationic compounds and assemblies exhibit a general antimicrobial action. In this work, cationic nanoparticles built from drug, cationic lipid and polyelectrolytes are shown to be excellent and active carriers of amphotericin B against C. albicans.
resultsAssemblies of amphotericin B and cationic lipid at extreme drug to lipid molar ratios were wrapped by polyelectrolytes forming cationic nanoparticles of high colloid stability and fungicidal activity against Candida albicans. Experimental strategy involved dynamic light scattering for particle sizing, zeta-potential analysis, colloid stability, determination of AmB aggregation state by optical spectra and determination of activity against Candida albicans in vitro from cfu countings.
conclusionNovel and effective cationic particles delivered amphotericin B to C. albicans in vitro with optimal efficiency seldom achieved from drug, cationic lipid or cationic polyelectrolyte in separate. The multiple assembly of antibiotic, cationic lipid and cationic polyelctrolyte, consecutively nanostructured in each particle produced a strategical and effective attack against the fungus cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.