ArticleArthritis research & therapy2008
Anti-cyclic citrullinated peptide antibodies in primary Sjögren syndrome may be associated with non-erosive synovitis.
Article in Arthritis research & therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 75 citations in OpenAlex.
- Non-Conventional and Emerging Autoantibodies in Sjögren's Disease.Journal of inflammation research · 2026Review
- Epidemiology of Sjögren syndrome.Nature reviews. Rheumatology · 2024Review
- Autoimmune markers in screening for orbital inflammatory disease.Eye (London, England) · 2023Article
- The role of albumin-to-globulin ratio in undifferentiated arthritis: Rheumatoid arthritis versus primary Sjögren syndrome.Archives of rheumatology · 2022Article
- Anti-Citrullinated Peptide Antibody Expression and Its Association with Clinical Features and Outcomes in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.Medicina (Kaunas, Lithuania) · 2022Article
- Not all autoantibodies are clinically relevant. Classic and novel autoantibodies in Sjögren's syndrome: A critical review.Frontiers in immunology · 2022Review
- Musculoskeletal Manifestations in Sjogren's Syndrome: An Orthopedic Point of View.Journal of clinical medicine · 2021Review
- Characterizing hand and wrist ultrasound pattern in primary Sjögren's syndrome: a case-control study.Clinical rheumatology · 2020Article
- Clinical and diagnostic significance of serum immunoglobulin A rheumatoid factor in primary Sjogren's syndrome.Clinical oral investigations · 2019Article
- Prognostic value of Sjögren's syndrome autoantibodies.Journal of laboratory and precision medicine · 2018Article
- Antibodies against carbamylated proteins are present in primary Sjögren's syndrome and are associated with disease severity.Annals of the rheumatic diseases · 2016Article
- Sjögren's syndrome: still not fully understood disease.Rheumatology international · 2015Review
- ACPA-positive primary Sjögren's syndrome: true primary or rheumatoid arthritis-associated Sjögren's syndrome?RMD open · 2015Article
- The epidemiology of Sjögren's syndrome.Clinical epidemiology · 2014Review
- Follow-up of primary Sjogren's syndrome patients presenting positive anti-cyclic citrullinated peptides antibody.Rheumatology international · 2013Article
- Posttranslational Protein Modification in the Salivary Glands of Sjögren's Syndrome Patients.Autoimmune diseases · 2013Article
- Joint involvement in primary Sjögren's syndrome: an ultrasound "target area approach to arthritis".BioMed research international · 2013Article
- The clinical significance of anti-cyclic citrullinated peptide antibody in primary Sjögren syndrome.Rheumatology international · 2012Article
- Prevalence of IgA class antibodies to cyclic citrullinated peptide (anti-CCP) in patients with primary Sjögren's syndrome, and its association to clinical manifestations.Clinical rheumatology · 2011Article
- Rheumatoid arthritis and smoking: putting the pieces together.Arthritis research & therapy · 2009Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe purpose of this study was to investigate the prevalence of cyclic citrullinated peptide antibodies (anti-CCP) in patients with primary Sjögren syndrome (pSS) and its correlation with clinical and laboratory data.
methodsWe analysed the clinical and serological data of 155 consecutive patients with pSS. Among these, 14 were excluded due to fulfillment of American College of Rheumatology criteria for rheumatoid arthritis (RA). So, 141 patients (27 males and 114 females; mean age 48 years, range 39 to 60) were clinically assessed for the presence of synovitis (objective swelling of one or more joints) and extra-glandular involvement. The anti-CCP antibodies were tested using a commercially available second-generation enzyme-linked immunosorbent assay. IgM rheumatoid factor (RF) was determined by nephelometry.
resultsFourteen patients (9.9%) had moderate to high levels of anti-CCP, and 94 (66.7%) were positive for RF. Eighty-one (57.4%) showed extra-glandular involvement, and 44 (31.2%) had synovitis without any radiographic sign of erosion. There was a close correlation between the presence of anti-CCP and synovitis (P < 0.001) but no association between anti-CCP and extra-glandular involvement (P = 0.77). Multivariate analysis confirmed the association between anti-CCP and an increased prevalence of synovitis (prevalence odds ratio for positive versus negative anti-CCP status 7.611, 95% confidence interval 1.475 to 74.870; P = 0.010).
conclusionOnly a minority of patients with pSS are anti-CCP-positive, which seems to be closely associated with the prevalence of synovitis. Anti-CCP positivity in patients with pSS therefore may be a predictor of future progress to RA or an expression of the inflammatory process of synovial tissue.
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