ArticleBrain pathology (Zurich, Switzerland)2009
Delineation of early changes in cases with progressive supranuclear palsy-like pathology. Astrocytes in striatum are primary targets of tau phosphorylation and GFAP oxidation.
Article in Brain pathology (Zurich, Switzerland), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
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- Interpretable Classification of Tauopathies with a Convolutional Neural Network Pipeline Using Transfer Learning and Validation against Post-Mortem Clinical Cases of Alzheimer's Disease and Progressive Supranuclear Palsy.Current issues in molecular biology · 2022Article
- Histologic lesion type correlates of magnetic resonance imaging biomarkers in four-repeat tauopathies.Brain communications · 2022Article
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- Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain.Acta neuropathologica communications · 2018Article
- Sisyphus in Neverland.Journal of Alzheimer's disease : JAD · 2018Article
- Protein astrogliopathies in human neurodegenerative diseases and aging.Brain pathology (Zurich, Switzerland) · 2017Review
- Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).Journal of neuropathology and experimental neurology · 2017Article
- Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases.Journal of neuropathology and experimental neurology · 2017Article
- The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease.Brain pathology (Zurich, Switzerland) · 2016Article
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- Abnormal Paraplegin Expression in Swollen Neurites, τ- and α-Synuclein Pathology in a Case of Hereditary Spastic Paraplegia SPG7 with an Ala510Val Mutation.International journal of molecular sciences · 2015Article
- Typical or atypical progressive supranuclear palsy: a comparative clinicopathologic study of three Chinese cases.International journal of clinical and experimental pathology · 2015Article
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2 authors at 1 institution in 1 country.
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Abstract
Progressive supranuclear palsy (PSP) is a complex tauopathy usually confirmed at post-mortem in advanced stages of the disease. Early PSP-like changes that may outline the course of the disease are not known. Since PSP is not rarely associated with argyrophilic grain disease (AGD) of varible intensity, the present study was focused on AGD cases with associated PSP-like changes in an attempt to delineate early PSP-like pathology in this category of cases. Three were typical clinical and pathological PSP. Another case presented with cognitive impairment, abnormal behavior and two falls in the last three months. One case suffered from mild cognitive impairment, and two had no evidence of neurological abnormality. Neuropathological study revealed, in addition to AGD, increased intensity and extent of lesion in three groups of regions, striatum, pallidus/subthalamus and selected nuclei of the brain stem, correlating with neurological impairment. Biochemical studies disclosed oxidative damage in the striatum and amygdala. Together the present observations suggest (i) early PSP-like lesions in the striatum, followed by the globus pallidus/subthalamus and selected nuclei of the brain stem; (ii) early involvement of neurons and astrocytes, but late appearance of tufted astrocytes; and (iii) oxidative damage of glial acidic protein in the striatum.
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