ArticleThe Journal of infectious diseases2008
Two quantitative trait loci influence whipworm (Trichuris trichiura) infection in a Nepalese population.
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching.PLoS pathogens · 2023Article
- Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching.bioRxiv : the preprint server for biology · 2023Article
- Effects of helminths on the human immune response and the microbiome.Mucosal immunology · 2022Review
- The Influence of Genetic and Environmental Factors and Their Interactions on Immune Response to Helminth Infections.Frontiers in immunology · 2022Review
- Whipworm and roundworm infections.Nature reviews. Disease primers · 2020Review
- Glycated Serum Protein Genetics and Pleiotropy with Cardiometabolic Risk Factors.Journal of diabetes research · 2019Article
- Risk factors for soil-transmitted helminth infections during the first 3 years of life in the tropics; findings from a birth cohort.PLoS neglected tropical diseases · 2014Article
- Host genetics and population structure effects on parasitic disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Article
- Maternal geohelminth infections are associated with an increased susceptibility to geohelminth infection in children: a case-control study.PLoS neglected tropical diseases · 2012Article
- A research agenda for helminth diseases of humans: basic research and enabling technologies to support control and elimination of helminthiases.PLoS neglected tropical diseases · 2012Review
- Human helminth co-infection: no evidence of common genetic control of hookworm and Schistosoma mansoni infection intensity in a Brazilian community.International journal for parasitology · 2010Article
- Nonsyndromic brachydactyly type D and type E mapped to 7p15 in healthy children and adults from the Jirel ethnic group in eastern Nepal.American journal of human biology : the official journal of the Human Biology CouncilArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWhipworm (Trichuris trichiura) infection is a soil-transmitted helminth infection that affects >1 billion people. It is a serious public health problem in many developing countries and can result in deficits in growth and cognitive development. In a follow-up study of significant heritability for whipworm infection, we conducted the first genome scan for quantitative trait loci (QTL) influencing the heritability of susceptibility to this important parasitic disease.
methodsWhipworm egg counts were determined for 1,253 members of the Jirel population of eastern Nepal. All individuals in the study sample belonged to a single pedigree including >26,000 pairs of relatives that are informative for genetic analysis.
resultsLinkage analysis of genome scan data generated for the pedigree provided unambiguous evidence for 2 QTL influencing susceptibility to whipworm infection, one located on chromosome 9 (logarithm of the odds ratio [LOD] score, 3.35; genomewide P = .0138) and the other located on chromosome 18 (LOD score, 3.29; genomewide P = .0159). There was also suggestive evidence that 2 loci located on chromosomes 12 and 13 influenced whipworm infection.
conclusionThe results of this first genome scan for T. trichiura egg counts provides new information on the determinants of genetic predisposition to whipworm infection.
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