ArticleThe Journal of infectious diseases2008
Role played by serum, a biological cue, in the adherence of Enterococcus faecalis to extracellular matrix proteins, collagen, fibrinogen, and fibronectin.
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Antibacterial potential of five phages in controlling Enterococcus faecalis and Enterococcus faecium.Virology journal · 2026Article
- Antibacterial and Anti-Adherence Efficacy of Silver Nanoparticles Against Endodontic Biofilms: An In Vitro and Ex Vivo Study.Pharmaceutics · 2025Article
- New understanding of gut microbiota and colorectal anastomosis leak: A collaborative review of the current concepts.Frontiers in cellular and infection microbiology · 2022Review
- Features and Colonization Strategies ofFrontiers in microbiology · 2022Article
- The enterococcal PASTA kinase: A sentinel for cell envelope stress.Molecular oral microbiology · 2021Review
- Cardiac Microlesions Form During Severe Bacteremic Enterococcus faecalis Infection.The Journal of infectious diseases · 2021Article
- Comparative genetics of Enterococcus faecalis intestinal tissue isolates before and after surgery in a rat model of colon anastomosis.PloS one · 2020Article
- Intestinal translocation of enterococci requires a threshold level of enterococcal overgrowth in the lumen.Scientific reports · 2019Article
- Biofilm Assays on Fibrinogen-coated Silicone Catheters and 96-well Polystyrene Plates.Bio-protocol · 2019Article
- Article
- Fibrinogen Release and Deposition on Urinary Catheters Placed during Urological Procedures.The Journal of urology · 2016Article
- The fibronectin-binding protein Fnm contributes to adherence to extracellular matrix components and virulence of Enterococcus faecium.Infection and immunity · 2015Article
- Article
- Frequency of ace, epa and elrA Genes in Clinical and Environmental Strains of Enterococcus faecalis.Indian journal of microbiology · 2012Article
- Conservation of Ebp-type pilus genes among Enterococci and demonstration of their role in adherence of Enterococcus faecalis to human platelets.Infection and immunity · 2011Article
- Relative contributions of Ebp Pili and the collagen adhesin ace to host extracellular matrix protein adherence and experimental urinary tract infection by Enterococcus faecalis OG1RF.Infection and immunity · 2011Article
- The transcriptome of the nosocomial pathogen Enterococcus faecalis V583 reveals adaptive responses to growth in blood.PloS one · 2009Article
- Adherence to host extracellular matrix and serum components by Enterococcus faecium isolates of diverse origin.FEMS microbiology letters · 2009Article
- Importance of the epa locus of Enterococcus faecalis OG1RF in a mouse model of ascending urinary tract infection.The Journal of infectious diseases · 2009Article
- Regulation of expression of the Haemophilus ducreyi LspB and LspA2 proteins by CpxR.Infection and immunity · 2009Article
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2 authors.
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Abstract
backgroundMost previous studies have found that Enterococcus faecalis isolates do not show significant adherence to fibronectin and fibrinogen.
methodsThe influence of various conditions on E. faecalis adherence to extracellular matrix (ECM) proteins was evaluated using a radiolabeled-cell adherence assay.
resultsAmong the conditions studied, growth in 40% horse serum (a biological cue with potential clinical relevance) elicited adherence of all 46 E. faecalis strains tested to fibronectin and fibrinogen but not to elastin; adherence levels were independent of strain source, and adherence was eliminated by treating cells with trypsin. As previously reported, serum also elicited adherence to collagen. Although prolonged exposure to serum during growth was needed for enhancement of adherence to fibrinogen, brief exposure (<5 min) to serum had an immediate, although partial, enhancing effect on adherence to fibronectin and, to a lesser extent, collagen; pretreatment of bacteria with chloramphenicol did not decrease this enhanced adherence to fibronectin and collagen, indicating that protein synthesis is not required for the latter effect.
conclusionTaken together, these data suggest that serum components may serve (1) as host environmental stimuli to induce the production of ECM protein-binding adhesin(s), as previously seen with collagen adherence, and also (2) as activators of adherence, perhaps by forming bridges between ECM proteins and adhesins.
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