ArticleJournal of virology1991
Promoter of the adenovirus polypeptide IX gene: similarity to E1B and inactivation by substitution of the simian virus 40 TATA element.
Article in Journal of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- Characterization of human adenovirus 35 and derivation of complex vectors.Virology journal · 2010Article
- Adenovirus as a carrier for the development of influenza virus-free avian influenza vaccines.Expert review of vaccines · 2009Review
- Profiling the thermodynamic softness of adenoviral promoters.Biophysical journal · 2008Article
- The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription.Genes & development · 1998Article
- The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression.Molecular and cellular biology · 1997Article
- An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor.Molecular and cellular biology · 1994Article
- Activation of the HLA-DRA gene in primary human T lymphocytes: novel usage of TATA and the X and Y promoter elements.Molecular and cellular biology · 1992Article
- Contribution of the TATA motif to Tat-mediated transcriptional activation of human immunodeficiency virus gene expression.Journal of virology · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The promoter of the adenovirus polypeptide IX (pIX) gene consists of an SP1 binding site and a TATA box and is remarkably similar to the promoter of the E1B gene in which it is nested. Plasmid constructs containing the pIX gene with deletions in the SP1 or TATA sites were defective in pIX mRNA production in transient expression assays. These results were confirmed with analogous virus constructs. An oligonucleotide containing sequences within the pIX promoter region spanning the SP1 and TATA sites but not including the sequences downstream of the TATA box is sufficient to direct mRNA synthesis at +90 nucleotides within the pIX gene. While the simian virus 40 (SV40) early promoter is capable of directing pIX mRNA synthesis from the SV40 cap sites, substitution of the pIX TATA box with the SV40 TATA box results in barely detectable levels of pIX mRNA. These results will be discussed with respect to exchangeability of promoter elements and the possible role of the viral E1B 21-kDa protein in potentiating or stabilizing transcription factor TFIID binding to the pIX TATA element.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.