ArticleWorld journal of gastroenterology2008
Efficacy of current guidelines for the treatment of spontaneous bacterial peritonitis in the clinical practice.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 104 citations in OpenAlex.
- Effect of alternative antibiotics in treatment of cefotaxime resistant spontaneous bacterial peritonitis.World journal of gastroenterology · 2013Trial
- Global Prevalence, Temporal Trends, and Associated Mortality of Bacterial Infections in Patients with Liver Cirrhosis: A Meta-analysis.Journal of clinical and translational hepatology · 2025Article
- How Do Polymorphonuclear Counts in Ascitic Fluid Correlate to Hospital Outcome.Journal of community hospital internal medicine perspectives · 2025Article
- Clinical Findings, Bacterial Agents, and Antibiotic Resistance in Children with Spontaneous Peritonitis in Southern Iran: An Academic Tertiary Referral Center's Experience.Iranian journal of medical sciences · 2024Article
- Article
- Listerial Spontaneous Bacterial Peritonitis.Cureus · 2022Article
- Clinical, Laboratory and Bacterial Profile of Spontaneous Bacterial Peritonitis in Vietnamese Patients with Liver Cirrhosis.Hepatic medicine : evidence and research · 2022Article
- [Pathogenic bacteria characteristics and antimicrobial treatment plan for liver cirrhosis combined with spontaneous bacterial peritonitis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021Article
- Antimicrobial resistance in patients with decompensated liver cirrhosis and bacterial infections in a tertiary center in Northern Germany.BMC gastroenterology · 2021Article
- Article
- Causative agents and outcome of spontaneous bacterial peritonitis in cirrhotic patients: community-acquired versus nosocomial infections.BMC infectious diseases · 2019Article
- Spontaneous bacterial peritonitis - therapeutic challenges in the era of increasing drug resistance of bacteria.Clinical and experimental hepatology · 2018Review
- Clinical and bacteriological features and prognosis of ascitic fluid infection in Chinese patients with cirrhosis.BMC infectious diseases · 2018Article
- Xuebijing Injection Combined with Antibiotics for the Treatment of Spontaneous Bacterial Peritonitis in Liver Cirrhosis: A Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- An Insight into Antibiotic Resistance to Bacterial Infection in Chronic Liver Disease.Journal of clinical and experimental hepatology · 2017Article
- A cost analysis of a broad-spectrum antibiotic therapy in the empirical treatment of health care-associated infections in cirrhotic patients.ClinicoEconomics and outcomes research : CEOR · 2017Article
- Role of albumin in cirrhosis: from a hospitalist's perspective.Journal of community hospital internal medicine perspectives · 2017Review
- Appropriateness of antibiotic usage for gastrointestinal disorders in a tertiary care hospital.European journal of hospital pharmacy : science and practice · 2016Article
- Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia.World journal of gastroenterology · 2016Observational
- PREVALENCE OF BACTERIAL RESISTANCE IN HOSPITALIZED CIRRHOTIC PATIENTS IN SOUTHERN BRAZIL: A NEW CHALLENGE.Revista do Instituto de Medicina Tropical de Sao Paulo · 2016Observational
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo verify the validity of the International Ascites Club guidelines for treatment of spontaneous bacterial peritonitis (SBP) in clinical practice.
methodsAll SBP episodes occurring in a group of consecutive cirrhotics were managed accordingly and included in the study. SBP was diagnosed when the ascitic fluid polymorphonuclear (PMN) cell count was > 250 cells/mm3, and empirically treated with cefotaxime.
resultsThirty-eight SBP episodes occurred in 32 cirrhotics (22 men/10 women; mean age: 58.6 +/- 11.2 years). Prevalence of SBP, in our population, was 17%. Ascitic fluid culture was positive in nine (24%) cases only. Eleven episodes were nosocomial and 71% community-acquired. Treatment with cefotaxime was successful in 59% of cases, while 41% of episodes required a modification of the initial antibiotic therapy because of a less-than 25% decrease in ascitic PMN count at 48 h. Change of antibiotic therapy led to the resolution of infection in 87% of episodes. Among the cases with positive culture, the initial antibiotic therapy with cefotaxime failed at a percentage (44%) similar to that of the whole series. In these cases, the isolated organisms were either resistant or with an inherent insufficient susceptibility to cefotaxime.
conclusionIn clinical practice, ascitic PMN count is a valid tool for starting a prompt antibiotic treatment and evaluating its efficacy. The initial treatment with cefotaxime failed more frequently than expected. An increase in healthcare-related infections with antibiotic-resistant pathogens may explain this finding. A different first-line antibiotic treatment should be investigated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.