ArticleThe Journal of comparative neurology2008
Synaptic input to dentate granule cell basal dendrites in a rat model of temporal lobe epilepsy.
Article in The Journal of comparative neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 54 citations in OpenAlex.
- Altered Physiology and Ensemble Recruitment of Dentate Gyrus Semilunar Granule Cells in a Mouse Model of Epilepsy.bioRxiv : the preprint server for biology · 2026Article
- Experimental early-life febrile seizures cause a sustained increase in excitatory neurotransmission in newborn dentate granule cells.Brain and behavior · 2022Article
- Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy.Nature communications · 2020Article
- Dendritic morphology and inhibitory regulation distinguish dentate semilunar granule cells from granule cells through distinct stages of postnatal development.Brain structure & function · 2020Article
- Targeting Seizure-Induced Neurogenesis in a Clinically Relevant Time Period Leads to Transient But Not Persistent Seizure Reduction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Construction and disruption of spatial memory networks during development.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Contributions of Adult-Generated Granule Cells to Hippocampal Pathology in Temporal Lobe Epilepsy: A Neuronal Bestiary.Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Repositioning of Somatic Golgi Apparatus Is Essential for the Dendritic Establishment of Adult-Born Hippocampal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Rabies tracing of birthdated dentate granule cells in rat temporal lobe epilepsy.Annals of neurology · 2017Article
- Enduring Memory Impairments Provoked by Developmental Febrile Seizures Are Mediated by Functional and Structural Effects of Neuronal Restrictive Silencing Factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Physical Exercise Restores the Generation of Newborn Neurons in an Animal Model of Chronic Epilepsy.Frontiers in neuroscience · 2017Article
- Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain.Experimental neurology · 2016Article
- Corruption of the dentate gyrus by "dominant" granule cells: Implications for dentate gyrus function in health and disease.Neurobiology of learning and memory · 2016Review
- Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline.Nature communications · 2015Article
- Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy.The Journal of comparative neurology · 2015Article
- Suppression of adult neurogenesis increases the acute effects of kainic acid.Experimental neurology · 2015Article
- Hippocampal granule cell pathology in epilepsy - a possible structural basis for comorbidities of epilepsy?Epilepsy & behavior : E&B · 2014Review
- Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation.Frontiers in molecular neuroscience · 2014Review
- Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Increased cell-intrinsic excitability induces synaptic changes in new neurons in the adult dentate gyrus that require Npas4.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In patients with temporal lobe epilepsy some dentate granule cells develop basal dendrites. The extent of excitatory synaptic input to basal dendrites is unclear, nor is it known whether basal dendrites receive inhibitory synapses. We used biocytin to intracellularly label individual granule cells with basal dendrites in epileptic pilocarpine-treated rats. An average basal dendrite had 3.9 branches, was 612 microm long, and accounted for 16% of a cell's total dendritic length. In vivo intracellular labeling and postembedding GABA-immunocytochemistry were used to evaluate synapses with basal dendrites reconstructed from serial electron micrographs. An average of 7% of 1,802 putative synapses were formed by GABA-positive axon terminals, indicating synaptogenesis by interneurons. Ninety-three percent of the identified synapses were GABA-negative. Most GABA-negative synapses were with spines, but at least 10% were with dendritic shafts. Multiplying basal dendrite length/cell and synapse density yielded an estimate of 180 inhibitory and 2,140 excitatory synapses per granule cell basal dendrite. Based on previous estimates of synaptic input to granule cells in control rats, these findings suggest an average basal dendrite receives approximately 14% of the total inhibitory and 19% of excitatory synapses of a cell. These findings reveal that basal dendrites are a novel source of inhibitory input, but they primarily receive excitatory synapses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.