ArticleEuropean journal of immunology2008
IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function.
Article in European journal of immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 99 citations in OpenAlex.
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- CD103+ CD11b+ Dendritic Cells Induce Th17 T Cells in Muc2-Deficient Mice with Extensively Spread Colitis.PloS one · 2015Article
- Systemic Activation of TLR3-Dependent TRIF Signaling Confers Host Defense against Gram-Negative Bacteria in the Intestine.Frontiers in cellular and infection microbiology · 2015Article
- Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man.Frontiers in immunology · 2015Review
- Pattern Recognition Receptors in Cancer Progression and Metastasis.Cancer growth and metastasis · 2015Review
- Contextual functions of antigen-presenting cells in the gastrointestinal tract.Immunological reviews · 2014Review
- The role of toll-like receptors in colorectal cancer progression: evidence for epithelial to leucocytic transition.Frontiers in immunology · 2014Review
- Blowing on embers: commensal microbiota and our immune system.Frontiers in immunology · 2014Review
- Toll-like receptor 2 as a regulator of oral tolerance in the gastrointestinal tract.Mediators of inflammation · 2014Review
- Location, location, location: tissue-specific regulation of immune responses.Journal of leukocyte biology · 2013Review
- NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense.Nature immunology · 2012Article
- Beyond pattern recognition: five immune checkpoints for scaling the microbial threat.Nature reviews. Immunology · 2012Article
- Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon.The Journal of experimental medicine · 2012Article
- Regulatory T cells and regulation of allergic airway disease.American journal of clinical and experimental immunology · 2012Article
- Genetically Modified Lactococcus lactis for Delivery of Human Interleukin-10 to Dendritic Cells.Gastroenterology research and practice · 2012Article
- Stromal regulation of human gastric dendritic cells restricts the Th1 response to Helicobacter pylori.Gastroenterology · 2011Article
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5 authors at 2 institutions in 2 countries.
Funding
Abstract
The default response of the intestinal immune system to most antigens is the induction of immunological tolerance, which is difficult to reconcile with the constant exposure to ligands for TLR and other pattern recognition receptors. We showed previously that dendritic cells (DC) from the lamina propria of normal mouse intestine may be inherently tolerogenic and here we have explored how this might relate to the expression and function of Toll-like receptors (TLR). Lamina propria (LP) DC showed higher levels of TLR 2, 3, 4 and 9 protein expression than spleen and MLN DC, with most TLR-expressing DC in the gut being CD11c(lo), class II MHC(lo), CD103(-), CD11b(-) and F4/80(-). TLR expression by lamina propria DC was low in the upper small intestine and higher in distal small intestine and colon. Freshly isolated lamina propria DC expressed some CD40, CD80, CD86 and functional CCR7. These were up-regulated on CD11c(lo), but not on CD11c(hi) LP DC by stimulation via TLR. However, there was little induction of IL-12 by either subset in response to TLR ligation. This was associated with constitutive IL-10 production and was reversed by blocking IL-10 function. Thus, IL-10 may maintain LP DC in a partially unresponsive state to TLR ligation, allowing them to have a critical role in immune homeostasis in the gut.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.