ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2008
Atomic force microscopy for imaging human metaphase chromosomes.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 47 citations in OpenAlex.
- Coffee-ring effect enables correlative super-resolution imaging of label-free chromosomes.Journal of the Royal Society, Interface · 2026Article
- Resolving interface structure and local internal mechanics of mitotic chromosomes.Nature communications · 2025Article
- Atomic force microscopy for characterization of decellularized extracellular matrix (dECM) based materials.Science and technology of advanced materials · 2024Review
- Direct observation of surface charge and stiffness of human metaphase chromosomes.Nanoscale advances · 2023Article
- Stochastic chromatin packing of 3D mitotic chromosomes revealed by coherent X-rays.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Scanning ion conductance microscopy of isolated metaphase chromosomes in a liquid environment.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2021Article
- Phase Separation and Histone Epigenetics in Genome Regulation.Current opinion in solid state & materials science · 2021Article
- Cryo-nanoscale chromosome imaging-future prospects.Biophysical reviews · 2020Review
- Localized, non-random differences in chromatin accessibility between homologous metaphase chromosomes.Molecular cytogenetics · 2014Article
- Tandemly repeated DNA families in the mouse genome.BMC genomics · 2011Article
- Replication Banding Patterns in Human Chromosomes Detected Using 5-ethynyl-2'-deoxyuridine Incorporation.Acta histochemica et cytochemica · 2011Article
- Atomic Force Microscope nanolithography on chromosomes to generate single-cell genetic probes.Journal of nanobiotechnology · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study introduces the principle of atomic force microscopy (AFM) and reviews our results of human metaphase chromosomes obtained by AFM. AFM imaging of the chromosomes revealed that the chromatid arm was not uniform in structure but had ridges and grooves along its length, which was most prominent in the late metaphase. The arrangement of these ridges and grooves was roughly symmetrical with the counterpart of the paired sister chromatids. AFM imaging of banded chromosomes also showed that the ridges and grooves were related to the G/Q-positive and G/Q-negative bands, respectively. At high magnification, the chromatid was seen to be produced by the compaction of highly twisted chromatin fiber loops, and its compaction tended to be stronger in the ridged regions of the chromosomes than in the grooved regions. Our AFM studies also showed the presence of catenation of chromatin fibers between the ridged portions of the chromatid in the late metaphase. Thus, AFM is useful for obtaining the three-dimensional surface topography not only in ambient conditions but also in physiological liquid conditions, and is expected to be an attractive tool for investigating the structure of chromosomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.