ArticleJournal of computational neuroscience2009
Dendrites determine the contribution of after depolarization potentials (ADPs) to generation of repetitive action potentials in hypothalamic gonadotropin releasing-hormone (GnRH) neurons.
Article in Journal of computational neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Dendritic interaction of timescales in afterdepolarization potentials and nonmonotonic spike-adding.Journal of computational neuroscience · 2026Article
- The electrophysiologic properties of gonadotropin-releasing hormone neurons.Journal of neuroendocrinology · 2022Review
- IInternational journal of molecular sciences · 2021Article
- Is realistic neuronal modeling realistic?Journal of neurophysiology · 2016Review
- A unified model for two modes of bursting in GnRH neurons.Journal of computational neuroscience · 2016Article
- Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neurons.American journal of physiology. Cell physiology · 2014Article
- Simulated GABA synaptic input and L-type calcium channels form functional microdomains in hypothalamic gonadotropin-releasing hormone neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A simple integrative electrophysiological model of bursting GnRH neurons.Journal of computational neuroscience · 2012Article
- Spatially selective, testosterone-independent remodeling of dendrites in gonadotropin-releasing hormone (GnRH) neurons prepubertally in male rats.Endocrinology · 2011Article
- Identified GnRH neuron electrophysiology: a decade of study.Brain research · 2010Review
- Altered GABAA receptor-mediated synaptic transmission disrupts the firing of gonadotropin-releasing hormone neurons in male mice under conditions that mimic steroid abuse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Two slow calcium-activated afterhyperpolarization currents control burst firing dynamics in gonadotropin-releasing hormone neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Dual somatic recordings from gonadotropin-releasing hormone (GnRH) neurons identified by green fluorescent protein (GFP) in hypothalamic slices.Journal of visualized experiments : JoVE · 2010Article
- Dendro-dendritic bundling and shared synapses between gonadotropin-releasing hormone neurons.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Ion channels and information processing in GnRH neuron dendrites.Channels (Austin, Tex.)Review
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3 authors at 1 institution in 1 country.
Funding
Abstract
The impact of structure in modulating synaptic signals originating in dendrites is widely recognized. In this study, we focused on the impact of dendrite morphology on a local spike generating mechanism which has been implicated in hormone secretion, the after depolarization potential (ADP). Using multi-compartmental models of hypothalamic GnRH neurons, we systematically truncated dendrite length and determined the consequence on ADP amplitude and repetitive firing. Decreasing the length of the dendrite significantly increased the amplitude of the ADP and increased repetitive firing. These effects were observed in dendrites both with and without active conductances suggesting they largely reflect passive characteristics of the dendrite. In order to test the findings of the model, we performed whole-cell recordings in GnRH neurons and elicited ADPs using current injection. During recordings, neurons were filled with biocytin so that we could determine dendritic and total projection (dendrite plus axon) length. Neurons exhibited ADPs and increasing ADP amplitude was associated with decreasing dendrite length, in keeping with the predictions of the models. Thus, despite the relatively simple morphology of the GnRH neuron's dendrite, it can still exert a substantial impact on the final neuronal output.
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