ArticleSexually transmitted diseases2008
Cost-effectiveness of screening strategies for Chlamydia trachomatis using cervical swabs, urine, and self-obtained vaginal swabs in a sexually transmitted disease clinic setting.
Article in Sexually transmitted diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Evaluation of Chlamydia trachomatis screening from the perspective of health economics: a systematic review.Frontiers in public health · 2023Pooled it
- Pooled it
- Vaginal Swab vs Urine for Detection ofAnnals of family medicinePooled it
- Effect of population-based antenatal screening and treatment of genitourinary tract infections on birth outcomes in Sylhet, Bangladesh (MIST): a cluster-randomised clinical trial.The Lancet. Global health · 2019Trial
- Screening and treatment of maternal genitourinary tract infections in early pregnancy to prevent preterm birth in rural Sylhet, Bangladesh: a cluster randomized trial.BMC pregnancy and childbirth · 2015Trial
- Assessment of best single sample for finding chlamydia in women with and without symptoms: a diagnostic test study.BMJ (Clinical research ed.) · 2012Trial
- Accuracy of self-collection versus cervical sampling for the molecular diagnosis ofRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- Annual STI Testing Among Sexually Active Adolescents.Pediatrics · 2022Article
- Cost-Effectiveness Analysis of Michigan's School-Wide Sexually Transmitted Disease Screening Program in Four Detroit High Schools.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2021Article
- Prevalence of and risk factors for abnormal vaginal flora and its association with adverse pregnancy outcomes in a rural district in north-east Bangladesh.Acta obstetricia et gynecologica Scandinavica · 2019Article
- Creating Innovative Sexually Transmitted Infection Testing Options for University Students: The Impact of an STI Self-testing Program.Sexually transmitted diseases · 2018Article
- Let's Take A "Selfie": Self-Collected Samples for Sexually Transmitted Infections.Sexually transmitted diseases · 2018Article
- Self-taken vaginal swabs versus clinician-taken for detection of candida and bacterial vaginosis: a case-control study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2017Article
- Cost-benefit analysis of Chlamydia trachomatis screening in pregnant women in a high burden setting in the United States.BMC infectious diseases · 2017Article
- Article
- Self-collected versus clinician-collected sampling for sexually transmitted infections: a systematic review and meta-analysis protocol.Systematic reviews · 2013Article
- Comparative effectiveness of a rapid point-of-care test for detection of Chlamydia trachomatis among women in a clinical setting.Sexually transmitted infections · 2013Article
- Acceptability of sexually transmitted infection testing using self-collected vaginal swabs among college women.Journal of American college health : J of ACH · 2013Article
- Comparative effectiveness of two self-collected sample kit distribution systems for chlamydia screening on a university campus.Sexually transmitted infections · 2012Article
- Cost-effectiveness analysis of Chlamydia trachomatis screening via internet-based self-collected swabs compared with clinic-based sample collection.Sexually transmitted diseases · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWe evaluated the cost-effectiveness of Chlamydia screening strategies that use different methods of specimen collection: cervical swabs, urines, and self-obtained vaginal swabs.
methodsA decision analysis was modeled for a hypothetical cohort of 10,000 per year of women attending sexually transmitted disease (STD) clinics. Incremental cost-effectiveness of 4 screening strategies were compared: 1) Endocervical DNA probe test (PACE2, Gen-Probe), 2) Endocervical AC2 (Aptima Combo 2, Gen-Probe), 3) Self-Obtained Vaginal AC2, and 4) Urine AC2. Sensitivities of the vaginal, urine, and cervical AC2 tests were derived from 324 women attending STD clinics. The primary outcome was cases of pelvic inflammatory disease prevented. The model incorporated programmatic screening and treatment costs and medical cost savings from sequelae prevented.
resultsChlamydia prevalence in the sampled population was 11.1%. Sensitivities of vaginal, urine, and cervical AC2 were 97.2%, 91.7%, and 91.7%, respectively. The sensitivity of the DNA probe was derived from the literature and estimated at 68.8%. The self-obtained vaginal AC2 strategy was the least expensive and the most cost-effective, preventing 17 more cases of pelvic inflammatory disease than the next least expensive strategy.
conclusionsUse of a vaginal swab to detect Chlamydia in this STD clinic population was cost-saving and cost-effective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.