ArticleNucleic acids research2008
Selection of a novel class of RNA-RNA interaction motifs based on the ligase ribozyme with defined modular architecture.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Engineering Crystal Packing in RNA Structures I: Past and Future Strategies for Engineering RNA Packing in Crystals.Crystals · 2021Article
- Single-Molecule Fluorescence Reveals Commonalities and Distinctions among Natural and in Vitro-Selected RNA Tertiary Motifs in a Multistep Folding Pathway.Journal of the American Chemical Society · 2017Article
- Article
- NMR monitoring of the SELEX process to confirm enrichment of structured RNA.Scientific reports · 2017Article
- The RNA 3D Motif Atlas: Computational methods for extraction, organization and evaluation of RNA motifs.Methods (San Diego, Calif.) · 2016Review
- An in vitro-selected RNA receptor for the GAAC loop: modular receptor for non-GNRA-type tetraloop.Nucleic acids research · 2013Article
- RNA plasticity and selectivity applicable to therapeutics and novel biosensor development.Genes to cells : devoted to molecular & cellular mechanisms · 2012Review
- Generation and development of RNA ligase ribozymes with modular architecture through "design and selection".Molecules (Basel, Switzerland) · 2010Review
- In vivo display of a multisubunit enzyme complex on biogenic magnetic nanoparticles.Applied and environmental microbiology · 2009Article
- Rational optimization of the DSL ligase ribozyme with GNRA/receptor interacting modules.Archives of biochemistry and biophysics · 2009Article
- A designed RNA selection: establishment of a stable complex between a target and selectant RNA via two coordinated interactions.Nucleic acids research · 2009Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
To develop molecular tools for the detection and control of RNA molecules whose functions rely on their 3D structures, we have devised a selection system to isolate novel RNA motifs that interact with a target RNA structure within a given structural context. In this system, a GAAA tetraloop and its specific receptor motif (11-ntR) from an artificial RNA ligase ribozyme with modular architecture (the DSL ribozyme) were replaced with a target structure and random sequence, respectively. Motifs recognizing the target structure can be identified by in vitro selection based on ribozyme activity. A model selection targeting GAAA-loop successfully identified motifs previously known as GAAA-loop receptors. In addition, a new selection targeting a C-loop motif also generated novel motifs that interact with this structure. Biochemical analysis of one of the C-loop receptor motifs revealed that it could also function as an independent structural unit.
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