ArticleThe British journal of ophthalmology2008
Mutations in the quinolone resistance determining region in Staphylococcus epidermidis recovered from conjunctiva and their association with susceptibility to various fluoroquinolones.
Article in The British journal of ophthalmology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 55 citations in OpenAlex.
- Current Recommendations, Antibiotic Resistance, and Emerging Treatments for Gram-Positive Ocular Infections in the United States.Antibiotics (Basel, Switzerland) · 2026Review
- Emerging threats and zoonotic implications of antibiotic-resistant Staphylococcus spp. in domesticated cats: a review.Antonie van Leeuwenhoek · 2026Review
- SkinApplied and environmental microbiology · 2026Article
- Species Distribution, Antimicrobial Resistance, and Enterotoxin Profiles of Non-Food science of animal resources · 2025Article
- Levofloxacin susceptibility of Staphylococci from conjunctiva in patients with atopic dermatitis.Japanese journal of ophthalmology · 2024Article
- Molecular and Phenotypic Characterization of Ocular Methicillin-Resistant Staphylococcus epidermidis Isolates in Taiwan.Investigative ophthalmology & visual science · 2023Article
- The Effects of Antiperspirant Aluminum Chlorohydrate on the Development of Antibiotic Resistance inMicroorganisms · 2023Article
- Genomic alterations involved in fluoroquinolone resistance development in Staphylococcus aureus.PloS one · 2023Article
- Concordance between Antimicrobial Resistance Phenotype and Genotype ofAntibiotics (Basel, Switzerland) · 2022Article
- Ocular surface flora and prophylactic antibiotics for cataract surgery in the age of antimicrobial resistance.Japanese journal of ophthalmology · 2022Review
- Photodegradation of fluoroquinolones in aqueous solution under light conditions relevant to surface waters, toxicity assessment of photoproduct mixtures.Environmental science and pollution research international · 2022Article
- Phenotypic and Genotypic Properties of Fluoroquinolone-Resistant,Microorganisms · 2021Article
- Comparative genomics ofMicrobial genomics · 2021Article
- Methicillin-ResistantMicroorganisms · 2021Article
- Genomic Analysis of Antibiotic-ResistantFrontiers in microbiology · 2021Article
- Systematic Investigation of Resistance Evolution to Common Antibiotics Reveals Conserved Collateral Responses across Common Human Pathogens.Antimicrobial agents and chemotherapy · 2020Article
- Fluoroquinolone resistance of Staphylococcus epidermidis isolated from healthy conjunctiva and analysis of their mutations in quinolone-resistance determining region.Antimicrobial resistance and infection control · 2020Article
- Prevalence and distribution of resistance and enterotoxins/enterotoxin-like genes in different clinical isolates of coagulase-negative Staphylococcus.European journal of medical research · 2020Article
- Acquisition Risk Factors of the SCCAntibiotics (Basel, Switzerland) · 2020Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStaphylococcus epidermidis is one of the prominent pathogens in ocular infection. The prevalence of mutations in the quinolone resistance determining region (QRDR) area in S epidermidis isolated from the ocular surface and its association with fluoroquinolone resistance has not been fully elucidated.
methodsMutations in the QRDR of gyrA, gyrB, parC, and parE genes of 138 isolates of S epidermidis recovered from the human conjunctival flora were analysed. The minimal inhibitory concentrations (MICs) of four fluoroquinolones (levofloxacin, gatifloxacin, moxifloxacin and tosufloxacin) against these isolates were also determined using agar dilution methods.
resultsThe MIC(90) values of levofloxacin, gatifloxacin, moxifloxacin and tosufloxacin were 3.13, 1.56, 0.78 and 3.13 microg/ml, respectively. The MIC values of all fluoroquinolones showed a bimodal distribution (susceptible strain and less susceptible strain). Mutations with amino acid substitution in the QRDR were present in 70 (50.7%) isolates. 19 different combinations of mutations were detected: 3 isolates (2.2%) had four mutations, 8 (5.8%) had three mutations, 43 (31.2%) had double mutations and 16 (11.6%) had single mutations. Isolates with mutations in the QRDR of both gyrA and parC (n = 53) were less susceptible to fluoroquinolones.
conclusionsThe present findings show that approximately half the S epidermidis isolates from the normal human conjunctiva have mutation(s) in the QRDR. The presence of mutations in both gyrA and parC is strongly associated with reduced susceptibility to fluoroquinolones.
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