ArticleMolecular biology and evolution2008
Long-term balancing selection at the west nile virus resistance gene, Oas1b, maintains transspecific polymorphisms in the house mouse.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Complex patterns shape immune genes diversity during invasion of common raccoon in Europe - Selection in action despite genetic drift.Evolutionary applications · 2023Article
- Balancing Selection Drives the Maintenance of Genetic Variation in Drosophila Antimicrobial Peptides.Genome biology and evolution · 2019Article
- Extensive shared polymorphism at non-MHC immune genes in recently diverged North American prairie grouse.Immunogenetics · 2018Article
- Intracellular Antiviral Immunity.Advances in virus research · 2018Review
- Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross.G3 (Bethesda, Md.) · 2017Article
- Functional evolution of the OAS1 viral sensor: Insights from old world primates.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Contrasted patterns of variation and evolutionary convergence at the antiviral OAS1 gene in old world primates.Immunogenetics · 2015Article
- Interspecific introgressive origin of genomic diversity in the house mouse.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?Journal of immunology research · 2015Review
- Long-term balancing selection at the antiviral gene OAS1 in Central African chimpanzees.Molecular biology and evolution · 2012Article
- Contrasting epidemic histories reveal pathogen-mediated balancing selection on class II MHC diversity in a wild songbird.PloS one · 2012Article
- Long-term balancing selection at the blood group-related gene B4galnt2 in the genus Mus (Rodentia; Muridae).Molecular biology and evolution · 2011Article
- Transspecies dimorphic allelic lineages of the proteasome subunit beta-type 8 gene (PSMB8) in the teleost genus Oryzias.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Identification of wild-derived inbred mouse strains highly susceptible to monkeypox virus infection for use as small animal models.Journal of virology · 2010Article
- High amino acid diversity and positive selection at a putative coral immunity gene (tachylectin-2).BMC evolutionary biology · 2010Article
- Evolutionary and functional properties of a two-locus beta-globin polymorphism in Indian house mice.Genetics · 2010Article
- Population genomics of parallel adaptation in threespine stickleback using sequenced RAD tags.PLoS genetics · 2010Article
- Introduction. Ecological immunology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Oligoadenylate synthetases (OASs) are interferon-inducible enzymes that participate in the first line of defense against a wide range of viral infection. Recent studies have determined that Oas1b, a member of the OAS gene family in the house mouse (Mus musculus), provides specific protection against flavivirus infection (e.g., West Nile virus, dengue fever virus, and yellow fever virus). We characterized the nucleotide sequence variation in coding and noncoding regions of the Oas1b gene for a large number of wild-derived strains of M. musculus and related species. Our sequence analyses determined that this gene is one of the most polymorphic genes ever described in any mammal. The level of variation in noncoding regions of Oas1b is an order of magnitude higher than the level reported for other regions of the mouse genome and is significantly different from the level of intraspecific variation expected under neutrality. Furthermore, a phylogenetic analysis of intronic sequences demonstrated that Oas1b alleles are ancient and that their divergence predates several speciation events, resulting in transspecific polymorphisms. The amino acid sequence of Oas1b is also extremely variable, with 1 out of 7 amino acid positions being polymorphic within M. musculus. Oas1b alleles are comparatively more divergent at synonymous positions than most autosomal genes and the ratio of nonsynonymous to synonymous substitution is remarkably high, suggesting that positive selection has been acting on Oas1b. The ancestry of Oas1b polymorphisms and the high level of amino acid polymorphisms strongly suggest that the allelic variation at Oas1b has been maintained in mouse populations by long-term balancing selection.
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