ReviewCurrent neurology and neuroscience reports2008
Pathophysiology of restless legs syndrome: evidence for iron involvement.
Review in Current neurology and neuroscience reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Adverse effects of antipsychotics on sleep in patients with schizophrenia. Systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Dopamine agonists for restless legs syndrome.The Cochrane database of systematic reviews · 2011Pooled it
- Levodopa for restless legs syndrome.The Cochrane database of systematic reviews · 2011Pooled it
- Evaluation of quality of life and depression in family caregivers of patients with type 1 diabetes in Iran: A case-control study.SAGE open medicine · 2023Article
- BTBD9 attenuates manganese-induced oxidative stress and neurotoxicity by regulating insulin growth factor signaling pathway.Human molecular genetics · 2022Article
- Iron, neuro-bioavailability and depression.EJHaem · 2022Review
- Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome Patients.Journal of clinical medicine · 2020Article
- Iron and manganese-related CNS toxicity: mechanisms, diagnosis and treatment.Expert review of neurotherapeutics · 2019Review
- Discovery of restless legs syndrome plasmatic biomarkers by proteomic analysis.Brain and behavior · 2018Article
- Contributions to magnetic susceptibility of brain tissue.NMR in biomedicine · 2017Review
- Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier.Frontiers in molecular neuroscience · 2015Review
- Sleep/wake problems in Parkinson's disease: pathophysiology and clinicopathologic correlations.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- T2 relaxometry using 3.0-tesla magnetic resonance imaging of the brain in early- and late-onset restless legs syndrome.Journal of clinical neurology (Seoul, Korea) · 2014Article
- Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome.The Journal of experimental medicine · 2013Article
- Restless legs syndrome, pica, and iron status in blood donors.Transfusion · 2013Article
- Iron's role in paediatric restless legs syndrome - a review.Paediatrics & child health · 2012Article
- Parkinson's disease and sleep/wake disturbances.Parkinson's disease · 2012Article
- Decreased CSF transferrin in sCJD: a potential pre-mortem diagnostic test for prion disorders.PloS one · 2011Article
- Restless legs syndrome: pathophysiology, clinical presentation and management.Nature reviews. Neurology · 2010Review
- Systems genetics analysis of iron regulation in the brain.Biochimie · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Neuroimaging, analysis of cerebrospinal fluid, and studies on postmortem tissue are generating data that support the concept that iron availability to the brain is a contributory process to, if not a cause of, restless legs syndrome. These data are reviewed and related to the dopaminergic system because of the use of dopamine agents in treating restless legs syndrome.
Indexed as
Identifiers
18460286What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.