Evidence map›Paper›PMID 18460265›Full record

ReviewCurrent rheumatology reports2008

Calcium and vitamin D: skeletal and extraskeletal health.

Natasha Khazai, Suzanne E Judd, Vin Tangpricha

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current rheumatology reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07766707 (Local and Systemic Inflammatory Bone Alterations Related to Dental Implant Survival.), which is not on this map. Cited by 181 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
181citing papers in PubMed, 12 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07766707 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Local and Systemic Inflammatory Bone Alterations Related to Dental Implant Survival.

TypeobservationalSponsorUniversity of BarcelonaRan2025 to 2027Enrolled192ConditionsPeri Implant Mucositis, Peri Implant Bone Loss, Peri Implantitis, Calcium Deficiency
3 · Its place in the literature

Who cites it

181 citing papers in PubMed, 12 syntheses or guidelines pooled it, 354 citations in OpenAlex.

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  6. Early-life famine exposure and risk of osteoporosis and low bone mineral density: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Pooled it
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  18. Interaction between vitamin D and the growth hormone/insulin-like growth factor 1 axis in children: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Review
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  20. Review

121 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Natasha KhazaiWoodruff Memorial Research Building, Room 1301, 101 Woodruff Circle Northeast, Atlanta, GA 30322, USA.
Suzanne E Judd
Vin Tangpricha
Woodruff Health Sciences Center · US

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Role of T-cells in Osteoporosis in Women Undergoing Surgical MenopauseK23AR054334 · NIAMS · EMORY UNIVERSITY · PI TANGPRICHA, VIN · 2007 to 2011
$641k
NCATS NIH HHS UL1 TR000454NIAMS NIH HHS K23 AR054334NIAMS NIH HHS K23AR054334
6 · The paper itself

Abstract

Vitamin D is known for its role in calcium homeostasis for optimal skeletal health. It was previously believed that only elderly or hospitalized patients were at risk for vitamin D insufficiency, but many people in the general US population have insufficient levels of 25-hydroxyvitamin D (25D). According to the Third National Health and Nutrition Examination Survey, 61% of white and 91% of black Americans suffer from vitamin D insufficiency (25D < 32 ng/mL). Recent studies have demonstrated that a minimum 25(OH)D level of 32 ng/mL is necessary for optimal protection from fracture and intestinal absorption of calcium. Recently, vitamin D has been recognized as important for extraskeletal functions such as immune function, cancer prevention, and hypertension prevention. We review the role of vitamin D in skeletal health and present data on vitamin D in other extraskeletal diseases, with special emphasis on the rheumatology patient.

Indexed as

OsteogenesisAccidental FallsBone Density Conservation AgentsCalciumErgocalciferolsFractures, BoneHumansRheumatic DiseasesVitamin D DeficiencyBone Density Conservation AgentsCalciumErgocalciferols

Identifiers

PMID18460265
PMCPMC2669834
OpenAlexW2074602211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.